Focal adhesion kinase (FAK) is both a non-receptor tyrosine kinase and an adaptor protein
that primarily regulates adhesion signalling and cell migration, but FAK can also promote …

Integrins mediate cell adhesion and transmit mechanical and chemical signals to the cell
interior. Various mechanisms deregulate integrin signaling in cancer, empowering tumor …

Focal adhesion kinase (FAK) is a cytoplasmic protein tyrosine kinase that is overexpressed
and activated in several advanced-stage solid cancers. FAK promotes tumour progression …

Focal adhesion kinase (FAK) is a key regulator of growth factor receptor-and integrin-
mediated signals, governing fundamental processes in normal and cancer cells through its …

Tumors are stiffer than normal tissue, and tumors have altered integrins. Because integrins
are mechanotransducers that regulate cell fate, we asked whether tissue stiffness could …

The metastatic process is highly inefficient—very few of the many cells that migrate from the
primary tumour successfully colonize distant sites. One proposed mechanism to explain this …

Integrins can alter cellular behavior through the recruitment and activation of signaling
proteins such as non-receptor tyrosine kinases including focal adhesion kinase (FAK) and c …

Exuberant fibroproliferation is a common complication after injury for reasons that are not
well understood. One key component of wound repair that is often overlooked is mechanical …

Pluripotency of embryonic stem cells (ESCs) and induced pluripotent stem cells is regulated
by a well characterized gene transcription circuitry. The circuitry is assembled by ESC …

Focal-adhesion kinase (FAK) is an important mediator of growth-factor signalling, cell
proliferation, cell survival and cell migration. Given that the development of malignancy is …