[HTML][HTML] SARS-CoV-2 pathogenesis

MM Lamers, BL Haagmans - Nature reviews microbiology, 2022 - nature.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
caused a devastating pandemic. Although most people infected with SARS-CoV-2 develop …

[HTML][HTML] Human organoid models to study SARS-CoV-2 infection

Y Han, L Yang, LA Lacko, S Chen - Nature Methods, 2022 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is one of the deadliest pandemics in history. SARS …

[HTML][HTML] Attenuated replication and pathogenicity of SARS-CoV-2 B. 1.1. 529 Omicron

H Shuai, JFW Chan, B Hu, Y Chai, TTT Yuen, F Yin… - Nature, 2022 - nature.com
Abstract The Omicron (B. 1.1. 529) variant of SARS-CoV-2 emerged in November 2021 and
is rapidly spreading among the human population. Although recent reports reveal that the …

[HTML][HTML] A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic

T Shapira, IA Monreal, SP Dion, DW Buchholz… - Nature, 2022 - nature.com
The COVID-19 pandemic caused by the SARS-CoV-2 virus remains a global public health
crisis. Although widespread vaccination campaigns are underway, their efficacy is reduced …

Human airway and nasal organoids reveal escalating replicative fitness of SARS-CoV-2 emerging variants

C Li, J Huang, Y Yu, Z Wan, MC Chiu… - Proceedings of the …, 2023 - National Acad Sciences
The high transmissibility of SARS-CoV-2 Omicron subvariants was generally ascribed to
immune escape. It remained unclear whether the emerging variants have gradually …

Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice

AC Hunt, JB Case, YJ Park, L Cao, K Wu… - Science translational …, 2022 - science.org
New variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue to
arise and prolong the coronavirus disease 2019 (COVID-19) pandemic. Here, we used a …

Spike mutations contributing to the altered entry preference of SARS-CoV-2 omicron BA. 1 and BA. 2

B Hu, JFW Chan, H Liu, Y Liu, Y Chai… - Emerging Microbes & …, 2022 - Taylor & Francis
ABSTRACT SARS-CoV-2 B. 1.1. 529.1 (Omicron BA. 1) emerged in November 2021 and
quickly became the predominant circulating SARS-CoV-2 variant globally. Omicron BA. 1 …

[HTML][HTML] A multi-organoid platform identifies CIART as a key factor for SARS-CoV-2 infection

X Tang, D Xue, T Zhang, BE Nilsson-Payant… - Nature Cell …, 2023 - nature.com
COVID-19 is a systemic disease involving multiple organs. We previously established a
platform to derive organoids and cells from human pluripotent stem cells to model SARS …

Drug combinations as a first line of defense against coronaviruses and other emerging viruses

JM White, JT Schiffer, RA Bender Ignacio, S Xu… - MBio, 2021 - Am Soc Microbiol
The world was unprepared for coronavirus disease 2019 (COVID-19) and remains ill-
equipped for future pandemics. While unprecedented strides have been made developing …

[PDF][PDF] Limited extent and consequences of pancreatic SARS-CoV-2 infection

V van der Heide, S Jangra, P Cohen, R Rathnasinghe… - Cell Reports, 2022 - cell.com
Concerns that infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2), the etiological agent of coronavirus disease 2019 (COVID-19), may cause new-onset …