Alzheimer's disease
In this Seminar, we highlight the main developments in the field of Alzheimer's disease. The
most recent data indicate that, by 2050, the prevalence of dementia will double in Europe …
most recent data indicate that, by 2050, the prevalence of dementia will double in Europe …
Sex and gender: modifiers of health, disease, and medicine
Clinicians can encounter sex and gender disparities in diagnostic and therapeutic
responses. These disparities are noted in epidemiology, pathophysiology, clinical …
responses. These disparities are noted in epidemiology, pathophysiology, clinical …
[HTML][HTML] Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer's disease
An unresolved question for the understanding of Alzheimer's disease (AD) pathophysiology
is why a significant percentage of amyloid-β (Aβ)-positive cognitively unimpaired (CU) …
is why a significant percentage of amyloid-β (Aβ)-positive cognitively unimpaired (CU) …
Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies
Polymorphism in the apolipoprotein E (APOE) gene is a major genetic risk determinant of
late-onset Alzheimer disease (AD), with the APOE* ε 4 allele conferring an increased risk …
late-onset Alzheimer disease (AD), with the APOE* ε 4 allele conferring an increased risk …
Novel tau biomarkers phosphorylated at T181, T217 or T231 rise in the initial stages of the preclinical Alzheimer's continuum when only subtle changes in Aβ …
In Alzheimer's disease (AD), tau phosphorylation in the brain and its subsequent release
into cerebrospinal fluid (CSF) and blood is a dynamic process that changes during disease …
into cerebrospinal fluid (CSF) and blood is a dynamic process that changes during disease …
[HTML][HTML] X-linked ubiquitin-specific peptidase 11 increases tauopathy vulnerability in women
Although women experience significantly higher tau burden and increased risk for
Alzheimer's disease (AD) than men, the underlying mechanism for this vulnerability has not …
Alzheimer's disease (AD) than men, the underlying mechanism for this vulnerability has not …
[HTML][HTML] APOE2: protective mechanism and therapeutic implications for Alzheimer's disease
Investigations of apolipoprotein E (APOE) gene, the major genetic risk modifier for
Alzheimer's disease (AD), have yielded significant insights into the pathogenic mechanism …
Alzheimer's disease (AD), have yielded significant insights into the pathogenic mechanism …
[HTML][HTML] Spread of pathological tau proteins through communicating neurons in human Alzheimer's disease
JW Vogel, Y Iturria-Medina, OT Strandberg… - Nature …, 2020 - nature.com
Tau is a hallmark pathology of Alzheimer's disease, and animal models have suggested that
tau spreads from cell to cell through neuronal connections, facilitated by β-amyloid (A β). We …
tau spreads from cell to cell through neuronal connections, facilitated by β-amyloid (A β). We …
Association of apolipoprotein E ε4 with medial temporal tau independent of amyloid-β
Importance Apolipoprotein E ε4 (APOEε4) is the single most important genetic risk factor for
Alzheimer disease. WhileAPOEε4is associated with increased amyloid-β burden, its …
Alzheimer disease. WhileAPOEε4is associated with increased amyloid-β burden, its …
Using the Alzheimer's Disease Neuroimaging Initiative to improve early detection, diagnosis, and treatment of Alzheimer's disease
DP Veitch, MW Weiner, PS Aisen… - Alzheimer's & …, 2022 - Wiley Online Library
Abstract Introduction The Alzheimer's Disease Neuroimaging Initiative (ADNI) has
accumulated 15 years of clinical, neuroimaging, cognitive, biofluid biomarker and genetic …
accumulated 15 years of clinical, neuroimaging, cognitive, biofluid biomarker and genetic …