The MET tyrosine kinase stimulates cell scattering, invasion, protection from apoptosis and
angiogenesis, thereby acting as a powerful expedient for cancer dissemination. MET can …

The development of oral squamous cell carcinoma (OSCC) is a multistep process requiring
the accumulation of multiple genetic alterations, influenced by a patient's genetic …

Malignant disease occurs when neoplastic cells abandon their primary site of accretion,
cross tissue boundaries and penetrate the vasculature to colonize distant sites. This process …

Non–small cell lung cancer (NSCLC) is a difficult disease to treat. The c-Met receptor is an
attractive potential target for novel therapeutic inhibition in human cancers. We provide …

The development of an altered stromal microenvironment is a common feature of many
tumours including squamous cell carcinoma (SCC), and there is increasing evidence that …

Recurrent/metastatic head and neck cancer remains a devastating disease with insufficient
treatment options. We investigated the MET receptor tyrosine kinase as a novel target for the …

Various cytokines and soluble growth factors upon interaction with their membrane
receptors are responsible for inducing cellular proliferation, differentiation, movement, and …

Emerging knowledge on how the dysregulated function of signaling networks contributes to
the malignant growth of squamous cell carcinoma of the head and neck (HNSCC) can now …

Hepatocyte growth factor (HGF) binds the extracellular domain and activates the Met
receptor to induce mitogenesis, morphogenesis, and motility. The extracellular domain of …

The MET proto-oncogene was first identified in osteosarcoma cells exposed to carcinogens.
Although expressed in many normal cells, MET is overexpressed in many human cancers …