Melanocytic nevi and melanoma: unraveling a complex relationship

WE Damsky, M Bosenberg - Oncogene, 2017 - nature.com
Approximately 33% of melanomas are derived directly from benign, melanocytic nevi.
Despite this, the vast majority of melanocytic nevi, which typically form as a result of BRAF …

The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia

BC Bastian - Annual Review of Pathology: Mechanisms of …, 2014 - annualreviews.org
Melanomas comprise multiple biologically distinct categories, which differ in cell of origin,
age of onset, clinical and histologic presentation, pattern of metastasis, ethnic distribution …

Lysosome-mediated processing of chromatin in senescence

A Ivanov, J Pawlikowski, I Manoharan… - Journal of Cell …, 2013 - rupress.org
Cellular senescence is a stable proliferation arrest, a potent tumor suppressor mechanism,
and a likely contributor to tissue aging. Cellular senescence involves extensive cellular …

Genomic aberrations in spitzoid melanocytic tumours and their implications for diagnosis, prognosis and therapy

T Wiesner, H Kutzner, L Cerroni, MC Mihm Jr… - Pathology, 2016 - Elsevier
Histopathological evaluation of melanocytic tumours usually allows reliable distinction of
benign melanocytic naevi from melanoma. More difficult is the histopathological …

Premature cell senescence in human skin: Dual face in chronic acquired pigmentary disorders

B Bellei, M Picardo - Ageing Research Reviews, 2020 - Elsevier
Although senescence was originally described as an in vitro acquired cellular characteristic,
it was recently recognized that senescence is physiologically and pathologically involved in …

mTORC1 activation blocks BrafV600E-induced growth arrest but is insufficient for melanoma formation

W Damsky, G Micevic, K Meeth, V Muthusamy… - Cancer cell, 2015 - cell.com
Braf V600E induces benign, growth-arrested melanocytic nevus development, but also
drives melanoma formation. Cdkn2a loss in Braf V600E melanocytes in mice results in rare …

[HTML][HTML] Vemurafenib induces senescence features in melanoma cells

S Haferkamp, A Borst, C Adam, TM Becker… - Journal of Investigative …, 2013 - Elsevier
A large proportion of human melanomas harbor a mutation leading to permanent activation
of the serine/threonine kinase BRAF, and as a consequence, they have developed …

Topical therapy for regression and melanoma prevention of congenital giant nevi

YS Choi, TH Erlich, M von Franque, I Rachmin… - Cell, 2022 - cell.com
Giant congenital melanocytic nevi are NRAS-driven proliferations that may cover up to 80%
of the body surface. Their most dangerous consequence is progression to melanoma. This …

The impact of cellular senescence in skin ageing: A notion of mosaic and therapeutic strategies

M Toutfaire, E Bauwens, F Debacq-Chainiaux - Biochemical pharmacology, 2017 - Elsevier
Cellular senescence is now recognized as one of the nine hallmarks of ageing. Recent data
show the involvement of senescent cells in tissue ageing and some age-related diseases …

CDKN2B Loss Promotes Progression from Benign Melanocytic Nevus to Melanoma

AS McNeal, K Liu, V Nakhate, CA Natale, EK Duperret… - Cancer discovery, 2015 - AACR
Deletion of the entire CDKN2B–CDKN2A gene cluster is among the most common genetic
events in cancer. The tumor-promoting effects are generally attributed to loss of CDKN2A …