Melanocytic nevi and melanoma: unraveling a complex relationship
WE Damsky, M Bosenberg - Oncogene, 2017 - nature.com
Approximately 33% of melanomas are derived directly from benign, melanocytic nevi.
Despite this, the vast majority of melanocytic nevi, which typically form as a result of BRAF …
Despite this, the vast majority of melanocytic nevi, which typically form as a result of BRAF …
The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia
BC Bastian - Annual Review of Pathology: Mechanisms of …, 2014 - annualreviews.org
Melanomas comprise multiple biologically distinct categories, which differ in cell of origin,
age of onset, clinical and histologic presentation, pattern of metastasis, ethnic distribution …
age of onset, clinical and histologic presentation, pattern of metastasis, ethnic distribution …
Lysosome-mediated processing of chromatin in senescence
A Ivanov, J Pawlikowski, I Manoharan… - Journal of Cell …, 2013 - rupress.org
Cellular senescence is a stable proliferation arrest, a potent tumor suppressor mechanism,
and a likely contributor to tissue aging. Cellular senescence involves extensive cellular …
and a likely contributor to tissue aging. Cellular senescence involves extensive cellular …
Genomic aberrations in spitzoid melanocytic tumours and their implications for diagnosis, prognosis and therapy
Histopathological evaluation of melanocytic tumours usually allows reliable distinction of
benign melanocytic naevi from melanoma. More difficult is the histopathological …
benign melanocytic naevi from melanoma. More difficult is the histopathological …
Premature cell senescence in human skin: Dual face in chronic acquired pigmentary disorders
B Bellei, M Picardo - Ageing Research Reviews, 2020 - Elsevier
Although senescence was originally described as an in vitro acquired cellular characteristic,
it was recently recognized that senescence is physiologically and pathologically involved in …
it was recently recognized that senescence is physiologically and pathologically involved in …
mTORC1 activation blocks BrafV600E-induced growth arrest but is insufficient for melanoma formation
W Damsky, G Micevic, K Meeth, V Muthusamy… - Cancer cell, 2015 - cell.com
Braf V600E induces benign, growth-arrested melanocytic nevus development, but also
drives melanoma formation. Cdkn2a loss in Braf V600E melanocytes in mice results in rare …
drives melanoma formation. Cdkn2a loss in Braf V600E melanocytes in mice results in rare …
[HTML][HTML] Vemurafenib induces senescence features in melanoma cells
S Haferkamp, A Borst, C Adam, TM Becker… - Journal of Investigative …, 2013 - Elsevier
A large proportion of human melanomas harbor a mutation leading to permanent activation
of the serine/threonine kinase BRAF, and as a consequence, they have developed …
of the serine/threonine kinase BRAF, and as a consequence, they have developed …
Topical therapy for regression and melanoma prevention of congenital giant nevi
Giant congenital melanocytic nevi are NRAS-driven proliferations that may cover up to 80%
of the body surface. Their most dangerous consequence is progression to melanoma. This …
of the body surface. Their most dangerous consequence is progression to melanoma. This …
The impact of cellular senescence in skin ageing: A notion of mosaic and therapeutic strategies
M Toutfaire, E Bauwens, F Debacq-Chainiaux - Biochemical pharmacology, 2017 - Elsevier
Cellular senescence is now recognized as one of the nine hallmarks of ageing. Recent data
show the involvement of senescent cells in tissue ageing and some age-related diseases …
show the involvement of senescent cells in tissue ageing and some age-related diseases …
CDKN2B Loss Promotes Progression from Benign Melanocytic Nevus to Melanoma
AS McNeal, K Liu, V Nakhate, CA Natale, EK Duperret… - Cancer discovery, 2015 - AACR
Deletion of the entire CDKN2B–CDKN2A gene cluster is among the most common genetic
events in cancer. The tumor-promoting effects are generally attributed to loss of CDKN2A …
events in cancer. The tumor-promoting effects are generally attributed to loss of CDKN2A …