Janus kinase (JAK) is a family of cytoplasmic non-receptor tyrosine kinases that includes
four members, namely JAK1, JAK2, JAK3, and TYK2. The JAKs transduce cytokine signaling …

Receptor tyrosine kinases (RTKs), a category of transmembrane receptors, have gained
significant clinical attention in oncology due to their central role in cancer pathogenesis …

Hyperactivated Janus kinase (JAK) signaling is an appreciated drug target in human
cancers. Numerous mutant JAK molecules as well as inherent and acquired drug resistance …

Tight regulation of IL-7Rα expression is essential for normal T-cell development. IL-7Rα gain-
of-function mutations are known drivers of T-cell acute lymphoblastic leukemia (T-ALL) …

Simple Summary Janus kinase/signal transducers and activators of transcription (JAK/STAT)
pathway is a crucial cell signaling pathway that drives the development, differentiation, and …

The polycomb repressive complex 2, with core components EZH2, SUZ12, and EED, is
responsible for writing histone 3 lysine 27 trimethylation histone marks associated with gene …

Disuse osteoporosis (DOP) is a common complication of the lack of mechanical loading. The
precise mechanism underlying DOP remains unknown, although epigenetic modifications …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy
derived from early T-cell progenitors. The recognition of clinical, genetic, transcriptional, and …

Resistance to mitochondrial apoptosis predicts inferior treatment outcomes in patients with
diverse tumor types, including T-cell acute lymphoblastic leukemia (T-ALL). However, the …

Simple Summary The suppressors of cytokine signaling (SOCS) are known cytokine-
inducible negative regulators of JAK/STAT and other cell signaling pathways. Deregulation …