Parkinson's disease: Mechanisms, translational models and management strategies

C Raza, R Anjum - Life sciences, 2019 - Elsevier
Parkinson's disease is a progressive neurodegenerative disorder. The classical motor
symptoms include resting tremors, bradykinesia, rigidity and postural instability and are …

[HTML][HTML] Alpha-synuclein research: defining strategic moves in the battle against Parkinson's disease

LMA Oliveira, T Gasser, R Edwards… - npj Parkinson's …, 2021 - nature.com
With the advent of the genetic era in Parkinson's disease (PD) research in 1997, α-synuclein
was identified as an important player in a complex neurodegenerative disease that affects> …

α-Synuclein phosphorylation at serine 129 occurs after initial protein deposition and inhibits seeded fibril formation and toxicity

SS Ghanem, NK Majbour, NN Vaikath… - Proceedings of the …, 2022 - National Acad Sciences
α-Synuclein (α-syn) phosphorylation at serine 129 (pS129–α-syn) is substantially increased
in Lewy body disease, such as Parkinson's disease (PD) and dementia with Lewy bodies …

Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies

C Peng, RJ Gathagan, DJ Covell, C Medellin, A Stieber… - Nature, 2018 - nature.com
In Lewy body diseases—including Parkinson's disease, without or with dementia, dementia
with Lewy bodies, and Alzheimer's disease with Lewy body co-pathology—α-synuclein (α …

The many faces of α-synuclein: from structure and toxicity to therapeutic target

HA Lashuel, CR Overk, A Oueslati… - Nature Reviews …, 2013 - nature.com
Disorders characterized by α-synuclein (α-syn) accumulation, Lewy body formation and
parkinsonism (and in some cases dementia) are collectively known as Lewy body diseases …

[HTML][HTML] Implication of alpha-synuclein phosphorylation at S129 in synucleinopathies: what have we learned in the last decade?

A Oueslati - Journal of Parkinson's disease, 2016 - content.iospress.com
Abnormal accumulation of proteinaceous intraneuronal inclusions called Lewy bodies (LBs)
is the neurpathological hallmark of Parkinson's disease (PD) and related synucleinopathies …

α-Synuclein in Parkinson's disease

L Stefanis - Cold Spring Harbor perspectives in …, 2012 - perspectivesinmedicine.cshlp.org
α-Synuclein is a presynaptic neuronal protein that is linked genetically and
neuropathologically to Parkinson's disease (PD). α-Synuclein may contribute to PD …

[HTML][HTML] Pathogenic impact of α-synuclein phosphorylation and its kinases in α-synucleinopathies

I Kawahata, DI Finkelstein, K Fukunaga - International journal of …, 2022 - mdpi.com
α-Synuclein is a protein with a molecular weight of 14.5 kDa and consists of 140 amino
acids encoded by the SNCA gene. Missense mutations and gene duplications in the SNCA …

What genetics tells us about the causes and mechanisms of Parkinson's disease

O Corti, S Lesage, A Brice - Physiological reviews, 2011 - journals.physiology.org
Parkinson's disease (PD) is a common motor disorder of mysterious etiology. It is due to the
progressive degeneration of the dopaminergic neurons of the substantia nigra and is …

Mechanistic basis for receptor-mediated pathological α-synuclein fibril cell-to-cell transmission in Parkinson's disease

S Zhang, YQ Liu, C Jia, YJ Lim… - Proceedings of the …, 2021 - National Acad Sciences
The spread of pathological α-synuclein (α-syn) is a crucial event in the progression of
Parkinson's disease (PD). Cell surface receptors such as lymphocyte activation gene 3 …