Antibodies are large protein assemblies capable of both specifically recognising antigens
and engaging with other proteins and receptors to coordinate immune action. Traditionally …

Humoral immunity to SARS-CoV-2 can be supplemented with polyclonal sera from
convalescent donors or an engineered monoclonal antibody (mAb) product. While …

Antibody-drug conjugates (ADCs) appear to be in a developmental boom, with five FDA
approvals in the last two years and a projected market value of over $4 billion by 2024 …

African swine fever is a widespread and highly contagious disease in the porcine
population, which is caused by African swine fever virus (ASFV). The PCR and ELISA …

Immunoglobulin M (IgM) is the largest antibody isotype with unique features like extensive
glycosylation and oligomerization. Major hurdles in characterizing its properties are …

Rationale: Fc engineering has become the focus of antibody drug development. The current
mutagenesis and in silico protein design methods are confined by the limited throughput …

The humanization of antibodies for therapeutics is a critical process that can determine the
success of antibody drug development. However, the science underpinning this process …

An international randomized phase II trial of Globo H (GH) vaccine, adagloxad
simolenin/OBI-821 in 349 patients with metastatic breast cancer showed longer progression …

Recent developments in the SARS-CoV-2 pandemic point to its inevitable transformation
into an endemic disease, urging both refinement of diagnostics for emerging variants of …

The binding affinity of trastuzumab and pertuzumab to HER2 has been studied using both
experimental and in silico methods. The experiments were conducted using the antibodies …