Stem cells represent natural units of embryonic development and tissue regeneration.
Embryonic stem (ES) cells, in particular, possess a nearly unlimited self-renewal capacity …

Embryonic stem (ES) cells have been established as permanent lines of undifferentiated
pluripotent cells from early mouse embryos. ES cells provide a unique system for the genetic …

Tissue-specific progenitor cells are characterized by proliferation and differentiation, but, in
contrast to embryonic stem (ES) cells, have limited capacities for self-renewal and no …

Mesenchymal stem cells (MSCs) are defined as cells that undergo sustained in vitro growth
and are able to give rise to multiple mesenchymal lineages. Although MSCs are already …

In the embryonic stem cell test (EST), differentiation of mouse embryonic stem cells (mESCs)
is used as a model to assess embryotoxicity in vitro. The test was successfully validated by …

Mouse embryonic stem (ES) cells differentiate into cells of all three primary germ layers
including endodermal cells that produce insulin in vitro. We show that constitutive …

Background—Human embryonic stem cells (hESCs) can be efficiently and reproducibly
directed into cardiomyocytes (CMs) using stage-specific induction protocols. However, their …

Nucleosome organization influences gene activity by controlling DNA accessibility to
transcription machinery. Here, we develop a chemical biology approach to determine …

Embryoid bodies (EBs) have been popular in vitro differentiation models for pluripotent stem
cells for more than five decades. Initially, defined as aggregates formed by embryonal …

West Nile virus (WNV) infects neurons and leads to encephalitis, paralysis, and death in
humans, animals, and birds. We investigated the mechanism by which neuronal injury …