In the last decades, evidence suggesting the direct or indirect involvement of B cells on
multiple sclerosis (MS) pathogenesis has accumulated. The increased amount of data on …

B cells are essential components of the adaptive immune system and have important roles
in the pathogenesis of several central nervous system (CNS) diseases. Besides producing …

Multiple sclerosis is an inflammatory demyelinating disease in which active demyelination
and neurodegeneration are associated with lymphocyte infiltrates in the brain. However, so …

A better understanding of the pathological mechanisms that drive neurodegeneration in
individuals with multiple sclerosis is needed to develop therapies that will effectively treat …

The central nervous system (CNS) comprises the brain, spinal cord, optic nerves and retina,
and contains post-mitotic, delicate cells. As the rigid coverings of the CNS render swelling …

Monoclonal antibodies that target CD20 expressing B cells represent an important new
treatment option for patients with multiple sclerosis (MS). B‐cell‐depleting therapy is highly …

Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS)
characterized by autoimmune-mediated demyelination and neurodegeneration. The CNS of …

Survival of plasma cells is regulated by B-cell maturation antigen (BCMA), a membrane-
bound receptor activated by its agonist ligands BAFF and APRIL. Here we report that γ …

MicroRNAs (miRNAs) are small noncoding RNAs that broadly affect cellular and
physiological function in all multicellular organisms. Here, the role of miRNAs in …

Interest in CD8+ T cells and B cells was initially inspired by observations in multiple
sclerosis rather than in animal models: CD8+ T cells predominate in multiple sclerosis …