Introduction Treatment of erectile dysfunction is based on pharmacotherapy for most
patients. Aim To review the current data on pharmacotherapy for erectile dysfunction based …

Abstract 1, 2, 3, 4-Tetrahydro-β-carboline (THβC) scaffold is widespread in many natural
products (NPs) and synthetic compounds which show a variety of pharmacological activities …

Kinetoplastids, including the human pathogens Trypanosoma brucei, Trypanosoma cruzi
and Leishmania, are the only known organisms that do not regulate the transcription of …

Infectious diseases are an enormous burden to global health and, since drug discovery is
costly, those infectious diseases that affect the developing world are often not pursued by …

Kinetoplastids are unicellular, eukaryotic, flagellated protozoans containing the eponymous
kinetoplast. Within this order, the family of trypanosomatids are responsible for some of the …

Protein kinase A (PKA), the main effector of cAMP in eukaryotes, is a paradigm for the
mechanisms of ligand-dependent and allosteric regulation in signalling. Here we report the …

Mycobacteria are endowed with rich and diverse machinery for the synthesis, utilization, and
degradation of cAMP. The actions of cyclic nucleotides are generally mediated by binding of …

Compared with the impressive progress in understanding signal transduction pathways and
mechanisms in mammalian systems, advances in protozoan signalling processes, including …

The dominant strategy for discovery of new antimalarial drugs relies on cell-free assays on
specific biochemical pathways of Plasmodium falciparum. However, it appears that …

Chagas disease is a tropical neglected disease endemic in Latin America caused by the
protozoan Trypanosoma cruzi. The parasite has four major life stages: epimastigote …