Antibiotic-induced decreases in the levels of microbial-derived short-chain fatty acids correlate with increased gastrointestinal colonization of Candida albicans

J Guinan, S Wang, TR Hazbun, H Yadav… - Scientific reports, 2019 - nature.com
Candida albicans is the fourth most common cause of systemic nosocomial infections,
posing a significant risk in immunocompromised individuals. As the majority of systemic C …

Development of Anti-Virulence Approaches for Candidiasis via a Novel Series of Small-Molecule Inhibitors of Candida albicans Filamentation

JA Romo, CG Pierce, AK Chaturvedi, AL Lazzell… - MBio, 2017 - Am Soc Microbiol
Candida albicans remains the main etiologic agent of candidiasis, the most common fungal
infection and now the third most frequent infection in US hospitals. The scarcity of antifungal …

Mechanisms of action of antimicrobial peptides ToAP2 and NDBP-5.7 against Candida albicans planktonic and biofilm cells

J do Nascimento Dias, C de Souza Silva… - Scientific reports, 2020 - nature.com
Candida albicans is a major cause of human infections, ranging from relatively simple to
treat skin and mucosal diseases to systemic life-threatening invasive candidiasis. Fungal …

Yeast and filaments have specialized, independent activities in a zebrafish model of Candida albicans infection

BG Seman, JL Moore, AK Scherer, BA Blair… - Infection and …, 2018 - Am Soc Microbiol
Candida albicans dimorphism is a crucial virulence factor during invasive candidiasis
infections, which claim the lives of nearly one-half of those afflicted. It has long been …

Characterization of an allosteric inhibitor of fungal-specific C-24 sterol methyltransferase to treat Candida albicans infections

X Jin, X Hou, X Wang, M Zhang, J Chen, M Song… - Cell Chemical …, 2023 - cell.com
Filamentation is an important virulence factor of the pathogenic fungus Candida albicans.
The abolition of Candida albicans hyphal formation by disrupting sterol synthesis is an …

Small molecules restore azole activity against drug-tolerant and drug-resistant Candida isolates

PE Alabi, C Gautier, TP Murphy, X Gu, M Lepas… - Mbio, 2023 - Am Soc Microbiol
Each year, fungi cause more than 1.5 billion infections worldwide and have a devastating
impact on human health, particularly in immunocompromised individuals or patients in …

Plasma activated Ezhangfeng Cuji as innovative antifungal agent and its inactivation mechanism

L Lin, Y Zhuo, Q Dong, C Yang, C Cheng, T Liu - AMB Express, 2023 - Springer
Candida albicans is a highly drug-resistant fungus for which new treatments are urgently
needed due to the lack of clinically effective options. In this study, we evaluated the …

A novel approach: targeting virulence factors of Candida albicans with essential oil components

AMA Shaban, H Darmani - Journal of Applied Microbiology, 2024 - academic.oup.com
Aims Focusing on phytochemicals to target the virulence factors of Candida albicans is a
promising avenue for novel antifungal compounds. Given the limited prior research on …

The effect of benzyl isothiocyanate on Candida albicans growth, cell size, morphogenesis, and ultrastructure

C Pereira, AM Calado, AC Sampaio - World Journal of Microbiology and …, 2020 - Springer
Candida albicans is a commensal yeast that may become pathogenic and even lethal to the
host. Over the last few decades, antifungal resistance has increased, promoting screening of …

Nanoemulsion as an effective treatment against human-pathogenic fungi

A Garcia, YY Fan, S Vellanki, EY Huh, DF Vanegas… - MSphere, 2019 - Am Soc Microbiol
Infections triggered by pathogenic fungi cause a serious threat to the public health care
system. In particular, an increase of antifungal drug-resistant fungi has resulted in difficulty in …