Introduction: Allostatic load refers to the cumulative burden of chronic stress and life events.
It involves the interaction of different physiological systems at varying degrees of activity …

Lesbian, gay, bisexual, and transgender (LGBT) populations experience significant health
disparities, theorized to result from LGBT specific minority stressors. The fully conceptualized …

Abstract Adverse Childhood Experiences (ACEs) are stressful and/or traumatic experiences
associated with an increased lifetime risk of negative health outcomes. The Allostatic Load …

For the last five decades, science has managed to delineate the mechanisms by which
stress hormones can impact on the human brain. Receptors for glucocorticoids are found in …

Once considered exclusively the cell's powerhouse, mitochondria are now recognized to
perform multiple essential functions beyond energy production, impacting most areas of cell …

Brain systems that promote the maintenance of homeostasis in face of stress have
significant adaptive value. A growing body of work across species demonstrates a critical …

Childhood multiple risk factor exposure exceeds the adverse developmental impacts of
singular exposures. Multiple risk factor exposure may also explain why sociodemographic …

The role of peripheral physiology in the experience of emotion has been debated since the
19th century following the seminal proposal by William James that somatic responses to …

Resilience science is quintessential developmental psychopathology because it focuses on
variation among individuals in relation to their experiences as they adapt and develop …

The assumption that early stress leads to dysregulation and impairment is widespread in
developmental science and informs prevailing models (eg, toxic stress). An alternative …