Novel CRISPR–Cas systems: an updated review of the current achievements, applications, and future research perspectives
According to Darwin's theory, endless evolution leads to a revolution. One such example is
the Clustered Regularly Interspaced Palindromic Repeats (CRISPR)–Cas system, an …
the Clustered Regularly Interspaced Palindromic Repeats (CRISPR)–Cas system, an …
[HTML][HTML] In vivo delivery of CRISPR-Cas9 therapeutics: Progress and challenges
Within less than a decade since its inception, CRISPR-Cas9-based genome editing has
been rapidly advanced to human clinical trials in multiple disease areas. Although it is highly …
been rapidly advanced to human clinical trials in multiple disease areas. Although it is highly …
Immunomodulation—a general review of the current state-of-the-art and new therapeutic strategies for targeting the immune system
M Strzelec, J Detka, P Mieszczak… - Frontiers in …, 2023 - frontiersin.org
In recent years, there has been a tremendous development of biotechnological,
pharmacological, and medical techniques which can be implemented in the functional …
pharmacological, and medical techniques which can be implemented in the functional …
The biology of the HIV-1 latent reservoir and implications for cure strategies
Antiretroviral therapy (ART) inhibits HIV replication but is not curative. During ART, the
integrated HIV genome persists indefinitely within CD4+ T cells and perhaps other cells …
integrated HIV genome persists indefinitely within CD4+ T cells and perhaps other cells …
Gene editing and CRISPR in the clinic: current and future perspectives
Genome editing technologies, particularly those based on zinc-finger nucleases (ZFNs),
transcription activator-like effector nucleases (TALENs), and CRISPR (clustered regularly …
transcription activator-like effector nucleases (TALENs), and CRISPR (clustered regularly …
Targeting herpes simplex virus with CRISPR–Cas9 cures herpetic stromal keratitis in mice
D Yin, S Ling, D Wang, Y Dai, H Jiang, X Zhou… - Nature …, 2021 - nature.com
Herpes simplex virus type 1 (HSV-1) is a leading cause of infectious blindness. Current
treatments for HSV-1 do not eliminate the virus from the site of infection or latent reservoirs in …
treatments for HSV-1 do not eliminate the virus from the site of infection or latent reservoirs in …
Curing HIV: seeking to target and clear persistent infection
Human immunodeficiency virus type 1 (HIV-1) infection persists despite years of
antiretroviral therapy (ART). To remove the stigma and burden of chronic infection …
antiretroviral therapy (ART). To remove the stigma and burden of chronic infection …
[HTML][HTML] The paradox of HIV blood–brain barrier penetrance and antiretroviral drug delivery deficiencies
HIV attacks the body's immune cells, frequently compromises the integrity of the blood–brain
barrier (BBB), and infects the CNS in the early stages of infection. Dysfunction of the BBB …
barrier (BBB), and infects the CNS in the early stages of infection. Dysfunction of the BBB …
HIV infects astrocytes in vivo and egresses from the brain to the periphery
V Lutgen, SD Narasipura, HJ Barbian… - PLoS …, 2020 - journals.plos.org
HIV invades the brain during acute infection. Yet, it is unknown whether long-lived infected
brain cells release productive virus that can egress from the brain to re-seed peripheral …
brain cells release productive virus that can egress from the brain to re-seed peripheral …
Genetically encoding multiple functionalities into extracellular vesicles for the targeted delivery of biologics to T cells
DM Stranford, LM Simons, KE Berman… - Nature biomedical …, 2023 - nature.com
The genetic modification of T cells has advanced cellular immunotherapies, yet the delivery
of biologics specifically to T cells remains challenging. Here we report a suite of methods for …
of biologics specifically to T cells remains challenging. Here we report a suite of methods for …