Alzheimer's disease (AD) is caused by synaptic and neuronal loss in the brain. One of the
characteristic hallmarks of AD is senile plaques containing amyloid β-peptide (Aβ). Aβ is …

Despite continuing debate about the amyloid β‐protein (or Aβ hypothesis, new lines of
evidence from laboratories and clinics worldwide support the concept that an imbalance …

We describe new tools for the processing of electron cryo-microscopy (cryo-EM) images in
the fourth major release of the RELION software. In particular, we introduce VDAM, a …

Here, we describe the third major release of RELION. CPU-based vector acceleration has
been added in addition to GPU support, which provides flexibility in use of resources and …

A new method to estimate the trajectories of particle motion and the amount of cumulative
beam damage in electron cryo-microscopy (cryo-EM) single-particle analysis is presented …

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron
microscopy | Nature Methods Skip to main content Thank you for visiting nature.com. You are …

Although the prevalence of dementia continues to increase worldwide, incidence in the
western world might have decreased as a result of better vascular care and improved brain …

The amyloid hypothesis for Alzheimer's disease (AD) posits a neuron-centric, linear cascade
initiated by Aβ and leading to dementia. This direct causality is incompatible with clinical …

Membrane lipids interact with proteins in a variety of ways, ranging from providing a stable
membrane environment for proteins to being embedded in to detailed roles in complicated …

Cryo-electron microscopy (cryo-EM) of non-crystalline single particles is a biophysical
technique that can be used to determine the structure of biological macromolecules and …