Cytokines play a pivotal role in maintaining bone homeostasis. Osteoclasts (OCs), the sole
bone resorbing cells, are regulated by numerous cytokines. Macrophage colony-stimulating …

The complicated connections and cross talk between the skeletal system and the immune
system are attracting more attention, which is developing into the field of Osteoimmunology …

Osteoimmunology is an interdisciplinary research field which combines the existing fields of
osteology (bone biology) and immunology under one umbrella. The observation that …

JAK/STAT signaling pathway is involved in many diseases, including autoimmune diseases,
which are characterized by a close interconnection between immune and bone system …

The β common chain (βc) cytokine family includes granulocyte-macrophage colony-
stimulating factor (GM-CSF), interleukin-3 (IL-3) and IL-5, all of which use βc as key …

Abstract IL‐17‐producing Th17 cells play an important role in pathogenesis of rheumatoid
arthritis (RA). Aberrant immune activation due to an imbalance between Th17 and regulatory …

Abstract Background Mesenchymal stem cells (MSCs) represent an important source for cell
therapy in regenerative medicine. MSCs have shown promising results for repair of …

IL-3, a cytokine secreted by activated T lymphocytes, is known to regulate the proliferation,
survival, and differentiation of hematopoietic cells. However, the role of IL-3 in regulation of T …

Both oxidative stress and inflammation are interdependent cellular consequences of a
biological defense system, which can fuel cancer and other pathophysiological provenience …

Osteoclasts can be differentiated from bone marrow-derived macrophages (BMDM). They
play a key role in bone resorption. Identifying novel molecules that can regulate …