Water is an essential participant in the stability, structure, dynamics, and function of proteins
and other biomolecules. Thermodynamically, changes in the aqueous environment affect …

In his memorable book published in 1949, The Physics of High Pressure, 1 Bridgman states
that “it is a well-known result of thermodynamics that a substance is only completely …

Highlights•Summary of the basic principles of structure-based vaccine design.•Review of
recent advances (the years 2019–2021) in structure-based vaccine design.•Preview of …

Although it is now relatively well understood how sequence defines and impacts global
protein stability in specific structural contexts, the question of how sequence modulates the …

Highlights•Mutational effects are consistently felt beyond the first shell of
interactions.•Mutations modulate the dynamics and chemical shifts of distal …

Mutations in the hydrophobic interior of proteins are generally thought to weaken the
interactions only in their immediate neighborhood. This forms the basis of protein …

High-pressure is a well-known perturbation method used to destabilize globular proteins. It
is perfectly reversible, which is essential for a proper thermodynamic characterization of a …

The time required to fold proteins usually increases significantly under conditions of high
pressure. Taking advantage of this general property of proteins, we combined P-jump …

Pressure and temperature are the two fundamental variables of thermodynamics.
Temperature and chemical perturbation are central experimental tools for the exploration of …

Understanding the extent to which information is transmitted through the intramolecular
interaction network of proteins upon a perturbation, that is, an allosteric effect, has long …