The evolution and ecology of bacterial warfare

ET Granato, TA Meiller-Legrand, KR Foster - Current biology, 2019 - cell.com
Bacteria have evolved a wide range of mechanisms to harm and kill their competitors,
including chemical, mechanical and biological weapons. Here we review the incredible …

Molecular regulation of antibiotic biosynthesis in Streptomyces

G Liu, KF Chater, G Chandra, G Niu… - … and molecular biology …, 2013 - Am Soc Microbiol
Streptomycetes are the most abundant source of antibiotics. Typically, each species
produces several antibiotics, with the profile being species specific. Streptomyces coelicolor …

Systems biology and biotechnology of Streptomyces species for the production of secondary metabolites

KS Hwang, HU Kim, P Charusanti, BØ Palsson… - Biotechnology …, 2014 - Elsevier
Streptomyces species continue to attract attention as a source of novel medicinal
compounds. Despite a long history of studies on these microorganisms, they still have many …

Specialised metabolites regulating antibiotic biosynthesis in Streptomyces spp.

G Niu, KF Chater, Y Tian, J Zhang… - FEMS Microbiology …, 2016 - academic.oup.com
Streptomyces bacteria are the major source of antibiotics and other secondary metabolites.
Various environmental and physiological conditions affect the onset and level of production …

Mathematical modelling of bacterial quorum sensing: a review

J Pérez-Velázquez, M Gölgeli… - Bulletin of mathematical …, 2016 - Springer
Bacterial quorum sensing (QS) refers to the process of cell-to-cell bacterial communication
enabled through the production and sensing of the local concentration of small molecules …

Recent advances in the biosynthesis of penicillins, cephalosporins and clavams and its regulation

G Ozcengiz, AL Demain - Biotechnology Advances, 2013 - Elsevier
The beta-lactam antibiotics have been serving mankind for over 70years. Despite this old
age, they continue to provide health to the world population by virtue of industrial production …

Phenotypic heterogeneity, a phenomenon that may explain why quorum sensing does not always result in truly homogenous cell behavior

J Grote, D Krysciak, WR Streit - Applied and environmental …, 2015 - Am Soc Microbiol
Phenotypic heterogeneity describes the occurrence of “nonconformist” cells within an
isogenic population. The nonconformists show an expression profile partially different from …

Developing an endogenous quorum-sensing based CRISPRi circuit for autonomous and tunable dynamic regulation of multiple targets in Streptomyces

J Tian, G Yang, Y Gu, X Sun, Y Lu… - Nucleic Acids …, 2020 - academic.oup.com
Quorum-sensing (QS) mediated dynamic regulation has emerged as an effective strategy for
optimizing product titers in microbes. However, these QS-based circuits are often created on …

Multi-level regulation of coelimycin synthesis in Streptomyces coelicolor A3(2)

B Bednarz, M Kotowska, KJ Pawlik - Applied microbiology and …, 2019 - Springer
Despite being a yellow pigment visible to the human eye, coelimycin (CPK) remained to be
an undiscovered secondary metabolite for over 50 years of Streptomyces research …

Comparative analysis of non-coding RNAs in the antibiotic-producing Streptomyces bacteria

MJ Moody, RA Young, SE Jones, MA Elliot - BMC genomics, 2013 - Springer
Abstract Background Non-coding RNAs (ncRNAs) are key regulatory elements that control a
wide range of cellular processes in all bacteria in which they have been studied. Taking …