Although clinical management of colon cancer generally has not accounted for the primary
tumor site, left-sided and right-sided colon cancers harbor different clinical and biologic …

Colorectal cancer (CRC) is the third most frequently detected type of cancer, and the second
most common cause of cancer-related mortality globally. The American Cancer Society …

Both genome-wide genetic and epigenetic alterations are fundamentally important for the
development of cancers, but the interdependence of these aberrations is poorly understood …

The advent of massively parallel sequencing technologies has allowed the characterization
of cancer genomes at an unprecedented resolution. Investigation of the mutational …

The acquisition of genomic instability is a crucial feature in tumor development and there are
at least 3 distinct pathways in colorectal cancer pathogenesis: the chromosomal instability …

Colorectal cancer (CRC) is a heterogeneous disease in which unique subtypes are
characterized by distinct genetic and epigenetic alterations. Here we performed …

Despite many studies of the likely survival outcome of individual patients with colorectal
cancer, our knowledge of this subject remains poor. Until recently, we had virtually no …

Cancer cells are shaped through an evolutionary process of DNA mutation, cell selection
and population expansion. Early steps in this process are driven by a set of mutated driver …

The acquisition of biallelic mutations in the APC gene is a rate-limiting step in the
development of most colorectal cancers and occurs in the earliest lesions. APC encodes a …

Purpose: Host immune response to tumor may be an important prognostic factor for colon
cancer patients. However, little is known on prognostic significance of histopathologic …