Albumosomes formed by cytoplasmic pre-folding albumin maintain mitochondrial homeostasis and inhibit nonalcoholic fatty liver disease

B Ma, A Ju, S Zhang, Q An, S Xu, J Liu, L Yu… - … and Targeted Therapy, 2023 - nature.com
Hepatic mitochondrial dysfunction contributes to the progression of nonalcoholic fatty liver
disease (NAFLD). However, the factors that maintain mitochondrial homeostasis, especially …

[HTML][HTML] Aging aggravates liver fibrosis through downregulated hepatocyte SIRT1-induced liver sinusoidal endothelial cell dysfunction

Q Dai, X Qing, W Jiang, S Wang, S Liu… - Hepatology …, 2024 - journals.lww.com
Background: Aging increases the susceptibility to chronic liver diseases and hastens liver
fibrosis deterioration, but the underlying mechanisms remain partially understood. The aim …

[HTML][HTML] Polyclonal antibodies selectively inhibit tumor growth and invasion and synergize with immune checkpoint inhibitors

C Ciron, P Morice, J Rousse, P Roy, PJ Royer… - JCI insight, 2024 - ncbi.nlm.nih.gov
Heterologous polyclonal antibodies (pAb) were shown to possess oncolytic properties a
century ago with reported clinical responses. More recent preclinical models confirmed pAb …

The size-dependent effects of nanoplastics in mouse primary hepatocytes from cells to molecules

Y Wang, X Zhao, H Tang, Z Wang, X Ge, S Hu, X Li… - Environmental …, 2024 - Elsevier
Nanoplastics (NPs) are easily ingested by organisms and their major accumulation organ
was determined to be liver. To date, the size-dependent cytotoxicity of NPs on mammalian …

Effect of sunitinib against Echinococcus multilocularis through inhibition of VEGFA-induced angiogenesis

H Jiang, X Wang, L Guo, X Tan, X Gui, Z Liao, Z Li… - Parasites & …, 2023 - Springer
Background Alveolar echinococcosis (AE) is a lethal zoonosis caused by the fox tapeworm
Echinococcus multilocularis. The disease is difficult to treat, and an effective therapeutic …

Isolation of primary mouse hepatocytes and non-parenchymal cells from a liver with precancerous lesions

F Lambertucci, O Motiño, M Pérez-Lanzón, S Li… - … : Methods and Protocols, 2024 - Springer
In the early stages of liver carcinogenesis, rare hepatocytes and cholangiocytes are
transformed into preneoplastic cells, which can progressively acquire a neoplastic …