The total and regional peripheral resistance and capacitance of the vascular system is
regulated by the sympathetic nervous system, which influences the vasculature mainly …

We have systematically reviewed the presence, functional responses and regulation of α1‐,
α2‐and β‐adrenoceptors in the bladder, urethra and prostate, with special emphasis on …

α1-Adrenoceptors are one of three subfamilies of receptors (α1, α2, β) mediating responses
to adrenaline and noradrenaline. Three α1-adrenoceptor subtypes are known (α1A, α1B …

G protein-coupled receptors (GPCRs) comprise the largest family of transmembrane
receptors and their signal transduction is tightly regulated by GPCR kinases (GRKs) and β …

BACKGROUND α1‐adrenoceptor antagonists (blockers) are now commonly used in the
treatment of the symptoms of lower urinary tract obstruction. Originally phenoxybenzamine, a …

Benign prostatic hyperplasia (BPH) is a common condition which currently accounts for
more than 0.5 million transurethral prostatectomies performed worldwide each year, being …

The α1-adrenergic receptors (ARs) are G-protein coupled receptors that bind the
endogenous catecholamines, norepinephrine, and epinephrine. They play a key role in the …

1 We review literature demonstrating (a) the presence and (b) the actions of substances that
mediate or modify neuroeffector transmission to the smooth muscle of the prostrate stroma of …

Abstract α1‐adrenoceptor antagonists are widely used for hypertension (eg, doxazosin) and
benign prostatic hypertrophy (BPH, eg, tamsulosin). Some antidepressants and …

Hypertension is one of the most serious health problems of the modern world with a
continuous rise in the number of patients. Selective α1-adrenoreceptor antagonists though …