Preclinical and clinical development of noncoding RNA therapeutics for cardiovascular disease
RNA modulation has become a promising therapeutic approach for the treatment of several
types of disease. The emerging field of noncoding RNA-based therapies has now come to …
types of disease. The emerging field of noncoding RNA-based therapies has now come to …
[PDF][PDF] Progress in multicellular human cardiac organoids for clinical applications
Advances in self-organizing cardiac organoids to recapitulate human cardiogenesis have
provided a powerful tool for unveiling human cardiac development, studying cardiovascular …
provided a powerful tool for unveiling human cardiac development, studying cardiovascular …
Biomaterializing the promise of cardiac tissue engineering
During an average individual's lifespan, the human heart pumps nearly 200 million liters of
blood delivered by approximately 3 billion heartbeats. Therefore, it is not surprising that …
blood delivered by approximately 3 billion heartbeats. Therefore, it is not surprising that …
[PDF][PDF] Effects of spaceflight on human induced pluripotent stem cell-derived cardiomyocyte structure and function
With extended stays aboard the International Space Station (ISS) becoming commonplace,
there is a need to better understand the effects of microgravity on cardiac function. We …
there is a need to better understand the effects of microgravity on cardiac function. We …
Key regulatory miRNAs in lipid homeostasis: Implications for cardiometabolic diseases and development of novel therapeutics
Dysregulation of lipid metabolism is associated with cardiovascular/metabolic diseases,
including atherosclerosis, liver diseases and type 2 diabetes mellitus (T2DM). Several …
including atherosclerosis, liver diseases and type 2 diabetes mellitus (T2DM). Several …
[HTML][HTML] Roles of reactive oxygen species in cardiac differentiation, reprogramming, and regenerative therapies
J Liang, M Wu, C Chen, M Mai, J Huang… - Oxidative medicine and …, 2020 - hindawi.com
Reactive oxygen species (ROS) have been implicated in mechanisms of heart development
and regenerative therapies such as the use of pluripotent stem cells. The roles of ROS …
and regenerative therapies such as the use of pluripotent stem cells. The roles of ROS …
Targeting the redox system for cardiovascular regeneration in aging
MS Allemann, P Lee, JH Beer, SS Saeedi Saravi - Aging Cell, 2023 - Wiley Online Library
Cardiovascular aging presents a formidable challenge, as the aging process can lead to
reduced cardiac function and heightened susceptibility to cardiovascular diseases …
reduced cardiac function and heightened susceptibility to cardiovascular diseases …
Cardiomyocyte induction and regeneration for myocardial infarction treatment: cell sources and administration strategies
L He, X Chen - Advanced Healthcare Materials, 2020 - Wiley Online Library
Occlusion of coronary artery and subsequent damage or death of myocardium can lead to
myocardial infarction (MI) and even heart failure—one of the leading causes of deaths world …
myocardial infarction (MI) and even heart failure—one of the leading causes of deaths world …
Sheathless acoustic fluorescence activated cell sorting (aFACS) with high cell viability
In this work, we demonstrate a sheathless acoustic fluorescence activated cell sorting
(aFACS) system by combining elasto-inertial cell focusing and highly focused traveling …
(aFACS) system by combining elasto-inertial cell focusing and highly focused traveling …
[HTML][HTML] Transplantation of human pluripotent stem cell-derived cardiomyocytes for cardiac regenerative therapy
Cardiovascular disease is the leading cause of death worldwide and bears an immense
economic burden. Late-stage heart failure often requires total heart transplantation; …
economic burden. Late-stage heart failure often requires total heart transplantation; …