A previous comparative-genomic study of large nuclear and cytoplasmic DNA viruses
(NCLDVs) of eukaryotes revealed the monophyletic origin of four viral families: poxviruses …

It is increasingly evident that metabolites suffer various kinds of damage, that such damage
happens in all organisms and that cells have dedicated systems for damage repair and …

We present a prototype of a new structural classification of proteins, SCOP2 (http://scop2.
mrc-lmb. cam. ac. uk/), that we have developed recently. SCOP2 is a successor to the …

Abstract The Structural Classification of Proteins (SCOP) database is a comprehensive
ordering of all proteins of known structure, according to their evolutionary and structural …

Three classes of low‐G+ C Gram‐positive bacteria (Firmicutes), Bacilli, Clostridia and
Negativicutes, include numerous members that are capable of producing heat‐resistant …

Tuberculosis, caused by Mycobacterium tuberculosis, remains a leading infectious disease
despite the availability of chemotherapy and BCG vaccine. The commonly used avirulent M …

For many bacteria with sequenced genomes, we do not understand how they synthesize
some amino acids. This makes it challenging to reconstruct their metabolism, and has led to …

Cellular metabolism constantly generates by‐products that are wasteful or even harmful.
Such compounds are excreted from the cell or are removed through hydrolysis to normal …

Introduction Breast tumors lacking the estrogen receptor-α (ER-α) have increased incidence
of resistance to therapy and poorer clinical prognosis. Methods Whole tissue sections from …

We have previously reported that mazEF, the first regulatable chromosomal 'addiction
module'located on the Escherichia coli chromosome, downstream from the relA gene, plays …