Drug resistance mechanisms and novel drug targets for tuberculosis therapy
Drug-resistant tuberculosis (TB) poses a significant challenge to the successful treatment
and control of TB worldwide. Resistance to anti-TB drugs has existed since the beginning of …
and control of TB worldwide. Resistance to anti-TB drugs has existed since the beginning of …
[HTML][HTML] The complex evolution of antibiotic resistance in Mycobacterium tuberculosis
Multidrug-resistant and extensively drug-resistant tuberculosis (TB) represent a major threat
to the control of the disease worldwide. The mechanisms and pathways that result in the …
to the control of the disease worldwide. The mechanisms and pathways that result in the …
Evolution and transmission of drug-resistant tuberculosis in a Russian population
N Casali, V Nikolayevskyy, Y Balabanova, SR Harris… - Nature …, 2014 - nature.com
The molecular mechanisms determining the transmissibility and prevalence of drug-resistant
tuberculosis in a population were investigated through whole-genome sequencing of 1,000 …
tuberculosis in a population were investigated through whole-genome sequencing of 1,000 …
Nosocomial transmission of extensively drug-resistant tuberculosis in a rural hospital in South Africa
NR Gandhi, D Weissman, P Moodley… - The Journal of …, 2013 - academic.oup.com
Background. Extensively drug-resistant tuberculosis (XDR-tuberculosis) is a global public
health threat, but few data exist elucidating factors driving this epidemic. The initial XDR …
health threat, but few data exist elucidating factors driving this epidemic. The initial XDR …
[HTML][HTML] Current status and future trends in the diagnosis and treatment of drug-susceptible and multidrug-resistant tuberculosis
S Ahmad, E Mokaddas - Journal of infection and public health, 2014 - Elsevier
The global burden of tuberculosis (TB) is still large. The increasing incidence of drug-
resistant, multidrug-resistant (MDR)(resistant to at least rifampicin and isoniazid), and …
resistant, multidrug-resistant (MDR)(resistant to at least rifampicin and isoniazid), and …
Whole Genome Sequencing of Mycobacterium tuberculosis Clinical Isolates From India Reveals Genetic Heterogeneity and Region-Specific Variations That Might …
Whole genome sequencing (WGS) of Mycobacterium tuberculosis has been constructive in
understanding its evolution, genetic diversity and the mechanisms involved in drug …
understanding its evolution, genetic diversity and the mechanisms involved in drug …
Sequence analysis for detection of first-line drug resistance in Mycobacterium tuberculosis strains from a high-incidence setting
S Feuerriegel, B Oberhauser, AG George, F Dafae… - BMC microbiology, 2012 - Springer
Background Drug resistance displays a problem for the therapy of Mycobacterium
tuberculosis infections. For molecular resistance testing, it is essential to have precise …
tuberculosis infections. For molecular resistance testing, it is essential to have precise …
Discordance across Phenotypic and Molecular Methods for Drug Susceptibility Testing of Drug-Resistant Mycobacterium tuberculosis Isolates in a Low TB Incidence …
S Ahmad, E Mokaddas, N Al-Mutairi, HS Eldeen… - PLoS …, 2016 - journals.plos.org
With increasing incidence of multidrug-resistant tuberculosis (MDR-TB), accurate drug
susceptibility testing (DST) of Mycobacterium tuberculosis to first-line drugs has become …
susceptibility testing (DST) of Mycobacterium tuberculosis to first-line drugs has become …
Screening for Streptomycin Resistance-Conferring Mutations in Mycobacterium tuberculosis Clinical Isolates from Poland
Currently, mutations in three genes, namely rrs, rpsL, and gidB, encoding 16S rRNA,
ribosomal protein S12, and 16S rRNA-specific methyltransferase, respectively, are …
ribosomal protein S12, and 16S rRNA-specific methyltransferase, respectively, are …
Mycobacterium tuberculosis functional genetic diversity, altered drug sensitivity, and precision medicine
S Stanley, Q Liu, SM Fortune - Frontiers in Cellular and Infection …, 2022 - frontiersin.org
In the face of the unrelenting global burden of tuberculosis (TB), antibiotics remain our most
effective tools to save lives and control the spread of Mycobacterium tuberculosis (Mtb) …
effective tools to save lives and control the spread of Mycobacterium tuberculosis (Mtb) …