Drug-resistant tuberculosis (TB) poses a significant challenge to the successful treatment
and control of TB worldwide. Resistance to anti-TB drugs has existed since the beginning of …

Multidrug-resistant and extensively drug-resistant tuberculosis (TB) represent a major threat
to the control of the disease worldwide. The mechanisms and pathways that result in the …

The molecular mechanisms determining the transmissibility and prevalence of drug-resistant
tuberculosis in a population were investigated through whole-genome sequencing of 1,000 …

Background. Extensively drug-resistant tuberculosis (XDR-tuberculosis) is a global public
health threat, but few data exist elucidating factors driving this epidemic. The initial XDR …

The global burden of tuberculosis (TB) is still large. The increasing incidence of drug-
resistant, multidrug-resistant (MDR)(resistant to at least rifampicin and isoniazid), and …

Whole genome sequencing (WGS) of Mycobacterium tuberculosis has been constructive in
understanding its evolution, genetic diversity and the mechanisms involved in drug …

Background Drug resistance displays a problem for the therapy of Mycobacterium
tuberculosis infections. For molecular resistance testing, it is essential to have precise …

With increasing incidence of multidrug-resistant tuberculosis (MDR-TB), accurate drug
susceptibility testing (DST) of Mycobacterium tuberculosis to first-line drugs has become …

Currently, mutations in three genes, namely rrs, rpsL, and gidB, encoding 16S rRNA,
ribosomal protein S12, and 16S rRNA-specific methyltransferase, respectively, are …

In the face of the unrelenting global burden of tuberculosis (TB), antibiotics remain our most
effective tools to save lives and control the spread of Mycobacterium tuberculosis (Mtb) …