Lys49 myotoxins, secreted phospholipase A2-like proteins of viperid venoms: A comprehensive review

B Lomonte - Toxicon, 2023 - Elsevier
Muscle necrosis is a potential clinical complication of snakebite envenomings, which in
severe cases can lead to functional or physical sequelae such as disability or amputation …

An in-depth exploration of snake venom-derived molecules for drug discovery in advancing antiviral therapeutics

H Hboub, RB Mrid, N Bouchmaa, N Oukkache… - Heliyon, 2024 - cell.com
Snake venom is a cocktail and rich source of various bioactive compounds that have been
extensively studied for their potential as pharmaceutical agents due to their diverse chemical …

Exploring antiviral and antiparasitic activity of gold N-heterocyclic carbenes with thiolate ligands

IS Oliveira, MSA Garcia, NM Cassani… - Dalton …, 2024 - pubs.rsc.org
Gold (I) N-heterocyclic carbenes have been explored for their therapeutic potential against
several diseases. Neglected tropical diseases, including leishmaniasis, Chagas disease …

Influence of diimine bidentate ligand in the nitrosyl and nitro terpyridine ruthenium complex on the HSA/DNA interaction and antiviral activity

NC Bessas, EC de Souza Arantes, NM Cassani… - Nitric Oxide, 2024 - Elsevier
Nitric oxide (NO) acts in different physiological processes, such as blood pressure control,
antiparasitic activities, neurotransmission, and antitumor action. Among the exogenous NO …

Discovery and structural optimization of a new series of N-acyl-2-aminobenzothiazole as inhibitors of Zika virus

RFC Dias, BMRM Ribeiro, NM Cassani… - Bioorganic & Medicinal …, 2023 - Elsevier
Zika virus infection is associated to severe diseases such as congenital microcephaly and
Zika fever causing serious harm to humans and special concern to health systems in low …

Effect of proteins isolated from Brazilian snakes on enterovirus A71 replication cycle: An approach against hand, foot and mouth disease

JF Shimizu, S Feferbaum-Leite, IA Santos… - International journal of …, 2023 - Elsevier
Abstract Enterovirus A71 (EVA71) belongs to the Picornaviridae family and is the main
etiological agent of hand, foot, and mouth disease (HFMD). There is no approved antiviral …

Antiviral Activity of Pd (II) Complexes with Aminoadamantanes Against Arboviruses

LB Silva, ÁB Cruz, DH Pereira, NM Cassani… - …, 2024 - Wiley Online Library
In this paper, we report the synthesis, structural characterization, and antiviral properties of
palladium (II) complexes with amantadine (atd) and memantine (mtn). Elemental and mass …

[HTML][HTML] Synthesis, Characterization and in vitro Evaluation of 4-(2-Aminoethyl)benzenesulfonamide Schiff Bases against Arboviruses

DH Nakahata, CESP Corsino, GC Morais… - Journal of the Brazilian …, 2024 - SciELO Brasil
This study presents the synthesis and characterization of five Schiff bases derived from the
reaction of 4-(2-aminoethyl)-benzenesulfonamide (compound 1) with corresponding …

Exploiting Venom Toxins in Paratransgenesis to Prevent Mosquito-Borne Disease

S French, R Da Silva, J Storm, CE Wastika, M ten Have… - 2024 - preprints.org
Mosquitoes are responsible for the transmission of numerous pathogens, including
Plasmodium parasites, arboviruses and filarial worms. They pose a significant risk to public …

Atividade antiviral de compostos sintéticos derivados do Benzotiazol na replicação do zika vírus in vitro

GA Antoniucci - 2024 - repositorio.ufu.br
O Orthoflavivirus zikaense (Zika vírus-ZIKV) é um arbovírus responsável pela Febre Zika.
Está relacionado com o desenvolvimento de complicações neurológicas como microcefalia …