Peroxisome proliferator–activated receptor α (PPAR α) is a nuclear receptor of clinical
interest as a drug target in various metabolic disorders. PPAR α also exhibits marked anti …

Peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription
factor belonging, together with PPARγ and PPARβ/δ, to the NR1C nuclear receptor …

Peroxisome proliferator-activated receptors (PPARs) are nuclear proteins that belong to the
superfamily of nuclear hormone receptors. They mediate the effects of small lipophilic …

The nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) is a key regulator
of adipocyte differentiation in vivo and ex vivo and has been shown to control the expression …

Thiazolidinediones (TZDs) are widely used to treat type 2 diabetes mellitus; however, their
use is complicated by systemic fluid retention. Along the nephron, the pharmacological …

Adipogenesis is tightly controlled by a complex network of transcription factors acting at
different stages of differentiation. Peroxisome proliferator‐activated receptor γ (PPARγ) and …

Peroxisome proliferator-activated receptor γ (PPARγ) and CCAAT/enhancer binding protein
α (C/EBPα) are key activators of adipogenesis. They mutually induce the expression of each …

It is becoming increasingly clear that transcription factors operate in complex networks
through thousands of genomic binding sites, many of which bind several transcription …

Adipocyte differentiation is tightly controlled by a transcriptional cascade, which directs the
extensive reprogramming of gene expression required to convert fibroblast-like precursor …

Long-chain fatty acyl-CoA esters are key intermediates in numerous lipid metabolic
pathways, and recognized as important cellular signaling molecules. The intracellular flux …