The recently discovered functions of RNA dramatically expand the cellular roles for this
macromolecule. RNA can no longer be viewed as a passive element, working simply as an …

1. Introduction 2222. What is an RNA motif? 2222.1 Sequence vs. structural motifs 2222.2
RNA structural motifs 2232.3 RNA structural elements vs. motifs 2232.4 Specific recognition …

Even though highly active anti-retroviral therapy is able to keep HIV-1 replication under
control, the virus can lie in a dormant state within the host genome, known as a latent …

Objective: The aim of this study was to measure the protein concentration and biological
activity of HIV-1 Tat in cerebrospinal fluid (CSF) of individuals on suppressive antiretroviral …

Methods for real-time, high-sensitivity polynucleotide detection are of vast scientific and
economic importance. Homogeneous biosensor assays that take advantage of the collective …

The visualization of RNA conformational changes has provided fundamental insights into
how regulatory RNAs carry out their biological functions. The RNA structural transitions that …

Identifying small molecules that selectively bind to structured RNA motifs remains an
important challenge in developing potent and specific therapeutics. Most strategies to find …

ABSTRACT RNA binding proteins recognize RNA targets in a sequence specific manner.
Apart from the sequence, the secondary structure context of the binding site also affects the …

Promoter-proximal pausing by RNA polymerase II (Pol II) is a key regulatory step in human
immunodeficiency virus-1 (HIV-1) transcription and thus in the reversal of HIV latency. By …

Enhancers confer precise spatiotemporal patterns of gene expression in response to
developmental and environmental stimuli. Over the last decade, the transcription of …