The brain harbors a unique ability to, figuratively speaking, shift its gears. During
wakefulness, the brain is geared fully toward processing information and behaving, while …

Alzheimer's disease (AD) is the most common cause of neurodegenerative dementia, whilst
Parkinson's disease (PD) is a neurodegenerative movement disorder. These two …

Aquaporin channels facilitate bidirectional water flow in all cells and tissues. AQP4 is highly
expressed in astrocytes. In the CNS, it is enriched in astrocyte endfeet, at synapses, and at …

Background Slowed clearance of amyloid β (Aβ) is believed to underlie the development of
Aβ plaques that characterize Alzheimer's disease (AD). Aβ is cleared in part by the …

The glymphatic system is a unique pathway that utilises end-feet Aquaporin 4 (AQP4)
channels within perivascular astrocytes, which is believed to cause cerebrospinal fluid …

Many neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease,
are characterised by the accumulation of misfolded protein deposits in the brain, leading to a …

The clearance function is essential for maintaining brain tissue homeostasis, and the
glymphatic system is the main pathway for removing brain interstitial solutes. Aquaporin-4 …

Cerebrospinal fluid plays a crucial role in protecting the central nervous system (CNS) by
providing mechanical support, acting as a shock absorber, and transporting nutrients and …

Aims Neurovascular-glymphatic dysfunction plays an important role in Alzheimer's disease
and has been analysed mainly in relation to amyloid-beta (Aβ) pathology. Here, we aim to …

Objective Aquaporin-4 (AQP4) facilitates a sleep-enhanced interstitial brain waste clearance
system. This study was conducted to determine the clinical implication of AQP4 …