The effect of statin therapy on endoplasmic reticulum stress
The endoplasmic reticulum (ER) is critical in protein processing and particularly in ensuring
that proteins undergo their correct folding to exert their functionality. What is becoming …
that proteins undergo their correct folding to exert their functionality. What is becoming …
[HTML][HTML] Airway mesenchymal cell death by mevalonate cascade inhibition: integration of autophagy, unfolded protein response and apoptosis focusing on Bcl2 family …
HMG-CoA reductase, the proximal rate-limiting enzyme in the mevalonate pathway, is
inhibited by statins. Beyond their cholesterol lowering impact, statins have pleiotropic effects …
inhibited by statins. Beyond their cholesterol lowering impact, statins have pleiotropic effects …
[HTML][HTML] TFEB SUMOylation in macrophages accelerates atherosclerosis by promoting the formation of foam cells through inhibiting lysosomal activity
K Wang, W Zhou, G Hu, L Wang, R Cai… - Cellular and Molecular Life …, 2023 - Springer
Atherosclerosis (AS) is a serious cardiovascular disease. One of its hallmarks is
hyperlipidemia. Inhibiting the formation of macrophage foam cells is critical for alleviating …
hyperlipidemia. Inhibiting the formation of macrophage foam cells is critical for alleviating …
[HTML][HTML] Phosphorylation of eIF2α attenuates statin-induced apoptosis by inhibiting the stabilization and translocation of p53 to the mitochondria
SK Lee, YS Kim - International journal of oncology, 2013 - spandidos-publications.com
Statins are effective cholesterol-lowering drugs that exert pleiotropic effects, including
cytotoxicity to cancer cells. We previously reported that simvastatin triggered the …
cytotoxicity to cancer cells. We previously reported that simvastatin triggered the …
[HTML][HTML] Chaperone insufficiency links TLR4 protein signaling to endoplasmic reticulum stress
A Coope, M Milanski, AP Arruda… - Journal of Biological …, 2012 - ASBMB
Inflammation plays an important pathogenic role in a number of metabolic diseases such as
obesity, type 2 diabetes, and atherosclerosis. The activation of inflammation in these …
obesity, type 2 diabetes, and atherosclerosis. The activation of inflammation in these …
[HTML][HTML] Atorvastatin improves survival in septic rats: effect on tissue inflammatory pathway and on insulin signaling
KL Calisto, BM Carvalho, ER Ropelle, FC Mittestainer… - PLoS …, 2010 - journals.plos.org
The aim of the present study was to investigate whether the survival-improving effect of
atorvastatin in sepsis is accompanied by a reduction in tissue activation of inflammatory …
atorvastatin in sepsis is accompanied by a reduction in tissue activation of inflammatory …
[HTML][HTML] Rosuvastatin protects against endothelial cell apoptosis in vitro and alleviates atherosclerosis in ApoE‑/‑mice by suppressing endoplasmic reticulum stress
J Geng, H Xu, W Fu, X Yu, G Xu… - Experimental and …, 2020 - spandidos-publications.com
The development of abnormal lipid‑induced atherosclerosis is initiated with endothelial cell
apoptosis. Vascular endothelial cells possess highly developed endoplasmic reticulum …
apoptosis. Vascular endothelial cells possess highly developed endoplasmic reticulum …
Simvastatin inhibits ox-LDL-induced inflammatory adipokines secretion via amelioration of ER stress in 3T3-L1 adipocyte
Z Wu, Y Chen, S Zhao - Biochemical and Biophysical Research …, 2013 - Elsevier
Adipocytes behave as a rich source of pro-inflammatory cytokines including tumor necrosis
factor-α (TNF-α) and monocyte chemoattractant protein 1 (MCP-1). Endoplasmic reticulum …
factor-α (TNF-α) and monocyte chemoattractant protein 1 (MCP-1). Endoplasmic reticulum …
[HTML][HTML] Dietary supplementation with essential amino acids boosts the beneficial effects of rosuvastatin on mouse kidney
G Corsetti, G D'Antona, C Ruocco, A Stacchiotti… - Amino Acids, 2014 - Springer
The effects of high-potency statins on renal function are controversial. To address the impact
of statins on renal morpho-functional aspects, normotensive young mice were treated with …
of statins on renal morpho-functional aspects, normotensive young mice were treated with …
PGC1α gene Gly482Ser polymorphism predicts improved metabolic, inflammatory and vascular outcomes following bariatric surgery
SR Geloneze, B Geloneze, J Morari… - International journal of …, 2012 - nature.com
Methods: Fifty-five patients (26 Gly/Gly and 29 Gly/Ser+ Ser/Ser) selected for the Roux-en-Y
gastric bypass according to the National Institutes of Health Consensus Statement criteria …
gastric bypass according to the National Institutes of Health Consensus Statement criteria …