The endoplasmic reticulum (ER) is critical in protein processing and particularly in ensuring
that proteins undergo their correct folding to exert their functionality. What is becoming …

HMG-CoA reductase, the proximal rate-limiting enzyme in the mevalonate pathway, is
inhibited by statins. Beyond their cholesterol lowering impact, statins have pleiotropic effects …

Atherosclerosis (AS) is a serious cardiovascular disease. One of its hallmarks is
hyperlipidemia. Inhibiting the formation of macrophage foam cells is critical for alleviating …

Statins are effective cholesterol-lowering drugs that exert pleiotropic effects, including
cytotoxicity to cancer cells. We previously reported that simvastatin triggered the …

Inflammation plays an important pathogenic role in a number of metabolic diseases such as
obesity, type 2 diabetes, and atherosclerosis. The activation of inflammation in these …

The aim of the present study was to investigate whether the survival-improving effect of
atorvastatin in sepsis is accompanied by a reduction in tissue activation of inflammatory …

The development of abnormal lipid‑induced atherosclerosis is initiated with endothelial cell
apoptosis. Vascular endothelial cells possess highly developed endoplasmic reticulum …

Adipocytes behave as a rich source of pro-inflammatory cytokines including tumor necrosis
factor-α (TNF-α) and monocyte chemoattractant protein 1 (MCP-1). Endoplasmic reticulum …

The effects of high-potency statins on renal function are controversial. To address the impact
of statins on renal morpho-functional aspects, normotensive young mice were treated with …

Methods: Fifty-five patients (26 Gly/Gly and 29 Gly/Ser+ Ser/Ser) selected for the Roux-en-Y
gastric bypass according to the National Institutes of Health Consensus Statement criteria …