Recent studies have revealed synaptic dysfunction to be a hallmark of various psychiatric
diseases, and that glial cells participate in synapse formation, development, and plasticity …

A versatile experimental model for the investigation of the blood-brain barrier (BBB),
including the neuro-vascular unit, is the isolated brain microvessel preparation. Brain …

The blood-brain barrier (BBB) is dysfunctional in temporal lobe epilepsy (TLE). In this
regard, microvascular changes are likely present. The aim of this review is to provide an …

Astrocytes play an important role in controlling microvascular diameter and regulating local
cerebral blood flow (CBF) in several physiological and pathological scenarios …

Seizures can result in a severe hypoperfusion/hypoxic attack that causes postictal memory
and behavioral impairments. However, neither postictal changes to microvasculature nor Ca …

In 2001, the concept of the neurovascular unit was introduced at the Stroke Progress Review
Group meeting. The neurovascular unit is an important element of the health and disease …

Epilepsy is one of the most common neurological disorders–estimated to affect at least 65
million worldwide. Most of the epilepsy research has so far focused on how to dampen …

Understanding the neurovascular coupling (NVC) underlying hemodynamic changes in
epilepsy is crucial to properly interpreting functional brain imaging signals associated with …

We employ transcranial wide-field single-photon imaging to compare genetically encoded
calcium sensors under transgenic or viral vector expression strategies. Awake, head-fixed …

Significance Perturbations in the microcirculatory system have been observed in
neurological conditions, such as Alzheimer's disease or systemic inflammation. However …