GM-CSF: A double-edged sword in cancer immunotherapy
A Kumar, A Taghi Khani, A Sanchez Ortiz… - Frontiers in …, 2022 - frontiersin.org
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a cytokine that drives the
generation of myeloid cell subsets including neutrophils, monocytes, macrophages, and …
generation of myeloid cell subsets including neutrophils, monocytes, macrophages, and …
The molecular details of cytokine signaling via the JAK/STAT pathway
More than 50 cytokines signal via the JAK/STAT pathway to orchestrate hematopoiesis,
induce inflammation and control the immune response. Cytokines are secreted …
induce inflammation and control the immune response. Cytokines are secreted …
SHP-2 and PD-1-SHP-2 signaling regulate myeloid cell differentiation and antitumor responses
The inhibitory receptor PD-1 suppresses T cell activation by recruiting the phosphatase SHP-
2. However, mice with a T-cell-specific deletion of SHP-2 do not have improved antitumor …
2. However, mice with a T-cell-specific deletion of SHP-2 do not have improved antitumor …
GM-CSF, IL-3, and IL-5 family of cytokines: regulators of inflammation
M Dougan, G Dranoff, SK Dougan - Immunity, 2019 - cell.com
The β common chain cytokines GM-CSF, IL-3, and IL-5 regulate varied inflammatory
responses that promote the rapid clearance of pathogens but also contribute to pathology in …
responses that promote the rapid clearance of pathogens but also contribute to pathology in …
[HTML][HTML] GM-CSF in inflammation
JA Hamilton - Journal of Experimental Medicine, 2020 - rupress.org
Granulocyte–macrophage colony-stimulating factor (GM-CSF) has many more functions
than its original in vitro identification as an inducer of granulocyte and macrophage …
than its original in vitro identification as an inducer of granulocyte and macrophage …
Molecular mechanisms that influence the macrophage M1–M2 polarization balance
N Wang, H Liang, K Zen - Frontiers in immunology, 2014 - frontiersin.org
As an essential component of innate immunity, macrophages have multiple functions in both
inhibiting or promoting cell proliferation and tissue repair. Diversity and plasticity are …
inhibiting or promoting cell proliferation and tissue repair. Diversity and plasticity are …
[HTML][HTML] The M1 and M2 paradigm of macrophage activation: time for reassessment
FO Martinez, S Gordon - F1000prime reports, 2014 - ncbi.nlm.nih.gov
Macrophages are endowed with a variety of receptors for lineage-determining growth
factors, T helper (Th) cell cytokines, and B cell, host, and microbial products. In tissues …
factors, T helper (Th) cell cytokines, and B cell, host, and microbial products. In tissues …
Selected cytokine pathways in rheumatoid arthritis
M Noack, P Miossec - Seminars in immunopathology, 2017 - Springer
Rheumatoid arthritis (RA) is a chronic inflammatory disease leading to joint destruction.
Cytokines play a key role in its pathogenesis. They contribute to the induction and …
Cytokines play a key role in its pathogenesis. They contribute to the induction and …
G-csf and gm-csf in neutropenia
HM Mehta, M Malandra, SJ Corey - The Journal of Immunology, 2015 - journals.aai.org
Abstract G-CSF and GM-CSF are used widely to promote the production of granulocytes or
APCs. The US Food and Drug Administration approved G-CSF (filgrastim) for the treatment …
APCs. The US Food and Drug Administration approved G-CSF (filgrastim) for the treatment …
Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement
AL Kalinski, C Yoon, LD Huffman, PC Duncker… - elife, 2020 - elifesciences.org
Sciatic nerve crush injury triggers sterile inflammation within the distal nerve and axotomized
dorsal root ganglia (DRGs). Granulocytes and pro-inflammatory Ly6Chigh monocytes …
dorsal root ganglia (DRGs). Granulocytes and pro-inflammatory Ly6Chigh monocytes …