The association of histones with specific chaperone complexes is important for their folding,
oligomerization, post-translational modification, nuclear import, stability, assembly and …

Organism viability relies on the stable maintenance of specific chromatin landscapes,
established during development, that shape cell functions and identities by driving distinct …

Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic …

The tail of replication-dependent histone H3. 1 varies from that of replication-independent
H3. 3 at the amino acid located at position 31 in plants and animals, but no function has …

After DNA replication, chromosomal processes including DNA repair and transcription take
place in the context of sister chromatids. While cell cycle regulation can guide these …

During S phase, replicated DNA must be assembled into nucleosomes using both newly
synthesized and parental histones in a process that is tightly coupled to DNA replication …

Nucleosomes compact and organize genetic material on a structural level. However, they
also alter local chromatin accessibility through changes in their position, through the …

From biosynthesis to assembly into nucleosomes, histones are handed through a cascade
of histone chaperones, which shield histones from non-specific interactions. Whether …

Histone H3 mutations at amino acids 27 (H3K27M) and 34 (H3G34R) are recurrent drivers
of pediatric-type high-grade glioma (pHGG). H3K27M mutations lead to global disruption of …

DNA replication is a challenge for the faithful transmission of parental information to
daughter cells, as both DNA and chromatin organization must be duplicated. Replication …