Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder with a
worldwide prevalence of about 1%, characterized by impairments in social interaction …

The perinatal period is associated with an increased risk of severe mental disorders. We
summarise the evidence regarding the epidemiology, risk factors, and treatment of severe …

Objectives To compare the time to treatment failure, remission and first seizure of 12 AEDs
(carbamazepine, phenytoin, sodium valproate, phenobarbitone, oxcarbazepine, lamotrigine …

Background Pregnant women with epilepsy frequently experience seizures related to
pregnancy complications and are often prescribed anti-epileptic drugs (AEDs) to manage …

Background Antenatal care of women with epilepsy is varied. The association of epilepsy
and antiepileptic drug exposure with pregnancy outcomes needs to be quantified to guide …

Background Prenatal exposure to antiepileptic drugs is associated with a greater risk of
major congenital malformations, but there is inadequate information on the comparative …

Objectives Compare the safety of antiepileptic drugs (AEDs) on neurodevelopment of
infants/children exposed in utero or during breast feeding. Design and setting Systematic …

Decisions about the use of psychotropic medication in pregnancy are an ongoing challenge
for clinicians and women with mental health problems, owing to the uncertainties around …

Valproic acid (VPA) is both an anti-convulsant and a mood stabilizer. Clinical studies over
the past 40years have shown that exposure to VPA in utero is associated with birth defects …

Background There is evidence that certain antiepileptic drugs (AEDs) are teratogenic and
are associated with an increased risk of congenital malformation. The majority of women …