Early-onset Alzheimer's disease (EOAD) is a rare but particularly devastating form of AD.
Though notable for its high degree of clinical heterogeneity, EOAD is defined by the same …

Abstract Purpose of Review Early-onset Alzheimer's disease (EOAD), defined as
Alzheimer's disease (AD) occurring before age 65, is significantly less well studied than the …

There is mounting evidence that only a small fraction of early-onset Alzheimer disease
cases (onset< 65 years) are explained by known mutations. Even multiplex families with …

Genetics has proven to be a powerful approach in neurodegenerative diseases research,
resulting in the identification of numerous causal and risk variants. Previously, we introduced …

Alzheimer's disease (AD) is the most common type of neurodegenerative dementia, but the
cause of AD remained poorly understood. Many mutations in the amyloid precursor protein …

Alzheimer's disease (AD) is the most common form of dementia, most prevalent in the
elderly population and has a significant impact on individuals and their family as well as the …

Abstract Knowledge of the molecular etiology of neurodegenerative brain diseases (NBD)
has substantially increased over the past three decades. Early genetic studies of NBD …

Alzheimer's disease (AD) is a disabling neurodegenerative disorder that leads to long-term
functional and cognitive impairment and greatly reduces life expectancy. Early genetic …

Sporadic early-onset Alzheimer's disease (sEOAD) exhibits the symptoms of late-onset
Alzheimer's disease but lacks the familial aspect of the early-onset familial form. The …

Objectives This study aimed to explore the relationship between 18 single nucleotide
polymorphisms (SNPs) and Alzheimer's disease (AD) within the southern Chinese …