Regulatory T cells are usually recognized as a specialized subset of CD4+ T cells
functioning in establishment and maintenance of immune tolerance. Meanwhile, there is …

Background: In vitro toxicology studies of tobacco and tobacco smoke have been used to
understand why tobacco use causes cancer and to assess the toxicologic impact of tobacco …

Naturally occurring regulatory T cells (T reg cells) are a thymus-derived subset of T cells,
which are crucial for the maintenance of peripheral tolerance by controlling potentially …

T regulatory (Treg) cells play a role in the suppression of immune responses, thus serving to
induce tolerance and control autoimmunity. Here, we explored whether Treg cells influence …

In the United States, more than 40% of cancer patients develop brain metastasis. The
median survival for untreated patients is 1 to 2 months, which may be extended to 6 months …

Brain metastases are highly resistant to chemotherapy. Metastatic tumor cells are known to
exploit the host microenvironment for their growth and survival. We report here that …

The coordination of complex tumor processes requires cells to rapidly modify their
phenotype and is achieved by direct cell-cell communication through gap junction channels …

The role of gap junctional intercellular communication (GJIC) in regulation of normal growth
and differentiation is becoming increasingly recognized as a major cellular function. GJIC …

T regulatory (Treg) cells are one of the key players in the immune tolerance network, and a
plethora of manuscripts have described their development and function in the course of the …

We hypothesized that regulatory T cells (Tregs) could play a beneficial role during HIV
infection by controlling HIV replication in conventional T cells (Tcons). Purified Tregs and …