Background Large cell neuroendocrine carcinoma (LCNEC) is a rare, aggressive cancer
with a dismal prognosis. The majority of cases occur in the lung and the gastrointestinal …

In 1999, the World Health Organization categorized large cell neuroendocrine carcinoma
(LCNEC) as a variant of large cell carcinoma. The World Health Organization categorization …

Purpose Pulmonary large-cell neuroendocrine carcinoma (LCNEC) is a relatively
uncommon, high-grade neuroendocrine tumor sharing several features with small-cell lung …

Background Large cell neuroendocrine carcinoma (LCNEC) accounts for approximately 3%
of lung cancers. Pathologic classification and optimal therapies are debated. We report the …

Although small cell carcinoma of the gastrointestinal (GI) tract is well-recognized, nonsmall
cell type high-grade neuroendocrine carcinoma (HGNEC) of this site remains undefined. At …

OBJECTIVE: Large cell neuroendocrine carcinomas of the lung display morphologic and
immunohistochemical characteristics common to neuroendocrine tumors and the …

Neuroendocrine carcinomas represent an important group of primary neoplasms in the lung.
During the last decades, the nomenclature of these tumors has evolved and the current use …

Background Large cell neuroendocrine carcinoma (LCNEC) represents a rare entity in non-
small cell lung cancer, with only partially understood biology and poor survival. A diagnosis …

To elucidate additional phenotypic differences between large cell neuroendocrine
carcinoma (LCNEC) and small cell lung carcinoma (SCLC), we performed tissue microarray …

INTRODUCTION: In non-surgical candidates with solitary pulmonary nodules (SPNs) and no
histological confirmation, optimal management remains uncertain. METHODS: Between …