Integration of retroviral DNA is an obligatory step of retrovirus replication because proviral
DNA is the template for productive infection. Integrase, a retroviral enzyme, catalyses …

Homo-oligomeric protein assemblies are known to participate in dynamic association/
disassociation equilibria under native conditions, thus creating an equilibrium of assembly …

Time-correlated single photon counting (TCSPC) is based on the detection of single photons
of a periodic light signal, measurement of the detection time of the photons, and the build-up …

Highly fluorescent nucleotide base analogs provide sensitive probes for studying the
structure, dynamics and interactions of nucleic acids. These analogs can be incorporated …

Proteins are involved in various equilibria that play a major role in their activity or regulation.
The design of molecules that shift such equilibria is of great therapeutic potential. This fact …

The oligomeric state of active human immunodeficiency virus type 1 (HIV-1) integrase (IN)
has not been clearly elucidated. We analyzed the activity of the different purified oligomeric …

This article presents the first evidence that the DNA base analogue 1, 3-diaza-2-
oxophenoxazine, tC O, is highly fluorescent, both as free nucleoside and incorporated in an …

The 3′-processing of the extremities of viral DNA is the first of two reactions catalyzed by
HIV-1 integrase (IN). High order IN multimers (tetramers) are required for complete …

Fluorescent oligonucleotides (FONs) are used in a wide variety of areas such as molecular
and mechanistics biological studies, molecular diagnostics, therapeutic development …

As a step toward the elucidation of the mechanistic pathways governing the known
bioactivity of polyoxometalates (POMs), two representative molecules of this class of …