Integrase and integration: biochemical activities of HIV-1 integrase
Integration of retroviral DNA is an obligatory step of retrovirus replication because proviral
DNA is the template for productive infection. Integrase, a retroviral enzyme, catalyses …
DNA is the template for productive infection. Integrase, a retroviral enzyme, catalyses …
Dynamic dissociating homo-oligomers and the control of protein function
T Selwood, EK Jaffe - Archives of Biochemistry and Biophysics, 2012 - Elsevier
Homo-oligomeric protein assemblies are known to participate in dynamic association/
disassociation equilibria under native conditions, thus creating an equilibrium of assembly …
disassociation equilibria under native conditions, thus creating an equilibrium of assembly …
Advanced time-correlated single photon counting techniques for spectroscopy and imaging in biomedical systems
W Becker, A Bergmann, GL Biscotti… - … Applications of Ultrafast …, 2004 - spiedigitallibrary.org
Time-correlated single photon counting (TCSPC) is based on the detection of single photons
of a periodic light signal, measurement of the detection time of the photons, and the build-up …
of a periodic light signal, measurement of the detection time of the photons, and the build-up …
Fluorescent nucleotide base analogs as probes of nucleic acid structure, dynamics and interactions
MJ Rist, JP Marino - Current Organic Chemistry, 2002 - ingentaconnect.com
Highly fluorescent nucleotide base analogs provide sensitive probes for studying the
structure, dynamics and interactions of nucleic acids. These analogs can be incorporated …
structure, dynamics and interactions of nucleic acids. These analogs can be incorporated …
Inhibiting HIV-1 integrase by shifting its oligomerization equilibrium
Z Hayouka, J Rosenbluh, A Levin… - Proceedings of the …, 2007 - National Acad Sciences
Proteins are involved in various equilibria that play a major role in their activity or regulation.
The design of molecules that shift such equilibria is of great therapeutic potential. This fact …
The design of molecules that shift such equilibria is of great therapeutic potential. This fact …
HIV-1 integrase crosslinked oligomers are active in vitro
A Faure, C Calmels, C Desjobert… - Nucleic acids …, 2005 - academic.oup.com
The oligomeric state of active human immunodeficiency virus type 1 (HIV-1) integrase (IN)
has not been clearly elucidated. We analyzed the activity of the different purified oligomeric …
has not been clearly elucidated. We analyzed the activity of the different purified oligomeric …
Characterization and use of an unprecedentedly bright and structurally non-perturbing fluorescent DNA base analogue
P Sandin, K Börjesson, H Li, J Mårtensson… - Nucleic acids …, 2008 - academic.oup.com
This article presents the first evidence that the DNA base analogue 1, 3-diaza-2-
oxophenoxazine, tC O, is highly fluorescent, both as free nucleoside and incorporated in an …
oxophenoxazine, tC O, is highly fluorescent, both as free nucleoside and incorporated in an …
Relationship between the oligomeric status of HIV-1 integrase on DNA and enzymatic activity
E Guiot, K Carayon, O Delelis, F Simon, P Tauc… - Journal of Biological …, 2006 - ASBMB
The 3′-processing of the extremities of viral DNA is the first of two reactions catalyzed by
HIV-1 integrase (IN). High order IN multimers (tetramers) are required for complete …
HIV-1 integrase (IN). High order IN multimers (tetramers) are required for complete …
Development and applications of fluorescent oligonucleotides
U Asseline - Current Organic Chemistry, 2006 - ingentaconnect.com
Fluorescent oligonucleotides (FONs) are used in a wide variety of areas such as molecular
and mechanistics biological studies, molecular diagnostics, therapeutic development …
and mechanistics biological studies, molecular diagnostics, therapeutic development …
Molecular interaction and energy transfer between human serum albumin and polyoxometalates
G Zhang, B Keita, JC Brochon… - The Journal of …, 2007 - ACS Publications
As a step toward the elucidation of the mechanistic pathways governing the known
bioactivity of polyoxometalates (POMs), two representative molecules of this class of …
bioactivity of polyoxometalates (POMs), two representative molecules of this class of …