Natural killer (NK) cells, a subgroup of innate lymphoid cells, act as the first line of defense
against cancer. Although some evidence shows that NK cells can develop in secondary …

T cell activation requires extracellular stimulatory signals that are mainly mediated by T cell
receptor (TCR) complexes. The TCR recognizes antigens on major histocompatibility …

Deciphering the cell-state transitions underlying immune adaptation across time is
fundamental for advancing biology. Empirical in vivo genomic technologies that capture …

Natural killer (NK) cells are effective in combating infections and tumors and as such are
tempting for adoptive transfer therapy. However, they are not homogeneous but can be …

Recent years have witnessed the discovery of an unprecedented complexity in innate
lymphocyte lineages, now collectively referred to as innate lymphoid cells (ILCs). ILCs are …

Natural killer (NK) cells belong to the innate immune system; they can control virus infections
and developing tumors by cytotoxicity and producing inflammatory cytokines. Most studies of …

Innate lymphoid cells (ILCs) are newly identified members of the lymphoid lineage that have
emerging roles in mediating immune responses and in regulating tissue homeostasis and …

Type 2 innate lymphoid cells (ILC2s) are part of a large family of ILCs that are important
effectors in innate immunity, lymphoid organogenesis, and tissue remodeling. ILC2s …

Natural killer (NK) cells play critical roles defending against tumors and pathogens. We
show that mice lacking both transcription factors Eomesodermin (Eomes) and T-bet failed to …

Natural killer (NK) cells survey host tissues for signs of infection, transformation or stress
and, true to their name, kill target cells that have become useless or are detrimental to the …