Progressive multifocal leukoencephalopathy (PML) is a devastating CNS infection caused
by JC virus (JCV), a polyomavirus that commonly establishes persistent, asymptomatic …

Progressive multifocal leukoencephalopathy (PML) is a debilitating and frequently fatal
central nervous system (CNS) demyelinating disease caused by JC virus (JCV), for which …

JC polyomavirus (JCPyV) was the first of now 12 PyVs detected in humans, when in 1964,
PyV particles were revealed by electron microscopy in progressive multifocal …

Many neurological diseases of the central nervous system (CNS) are underpinned by
malfunctions of the immune system, including disorders involving opportunistic infections …

JC polyomavirus (JCPyV) is the causative agent of a fatal central nervous system
demyelinating disease known as progressive multifocal leukoencephalopathy (PML). PML …

Natalizumab, an antibody against the α4 subunit of α4 integrins, has been approved for
multiple sclerosis (MS) therapy based on its high efficacy and safety profile. However …

John Cunningham virus (JCV) is a member of the Polyomaviridae family. It was first isolated
from the brain of a patient with Hodgkin disease in 1971, and since then the etiological …

JC and BK polyomaviruses were discovered over 40 years ago and have become
increasingly prevalent causes of morbidity and mortality in a variety of distinct …

Progressive multifocal leukoencephalopathy (PML) is an opportunistic viral disease of the
brain—caused by human polyomavirus 2. It affects patients whose immune system is …

The increased use of newer potent immunomodulatory therapies for multiple sclerosis (MS),
including natalizumab, fingolimod, and dimethyl fumarate, has expanded the patient …