Ribosomopathies are diseases caused by defects in ribosomal constituents or in factors with
a role in ribosome assembly. Intriguingly, congenital ribosomopathies display a paradoxical …

Ribosomopathies compose a collection of disorders in which genetic abnormalities cause
impaired ribosome biogenesis and function, resulting in specific clinical phenotypes …

When considering the control of gene expression, the focus has traditionally been on
transcriptional regulation. Recently, however, the large contribution made by mRNA decay …

At different stages of any research project, molecular biologists need to choose—often
somewhat arbitrarily, even after careful statistical data analysis—which genes or proteins to …

The role of RNA polymerase (Pol) III in eukaryotic transcription is commonly thought of as
being restricted to a small set of highly expressed, housekeeping non–protein-coding (nc) …

The underlying cause of mental retardation remains unknown in up to 80% of patients. As
chromosomal aberrations are the most common known cause of mental retardation, several …

p53 inactivation is highly associated with tumorigenesis and drug resistance. Here, we
identify a long noncoding RNA, the RNA component of mitochondrial RNA-processing …

Evidence from many sources suggests that similar phenotypes are begotten by functionally
related genes. This is most obvious in the case of genetically heterogeneous diseases such …

The diagnostic yield of exome and genome sequencing remains low (8–70%), due to
incomplete knowledge on the genes that cause disease. To improve this, we use RNA-seq …

RNA polymerase (Pol) III is responsible for transcription of different noncoding genes in
eukaryotic cells, whose RNA products have well-defined functions in translation and other …