The community of cells lining our airways plays a collaborative role in the preservation of
immune homeostasis in the lung and provides protection from the pathogens and pollutants …

The immune system is highly time-of-day dependent. Pioneering studies in the 1960s were
the first to identify immune responses to be under a circadian control. Only in the last …

Recent discoveries demonstrate a critical role for circadian rhythms and sleep in immune
system homeostasis. Both innate and adaptive immune responses—ranging from leukocyte …

Nuclear receptor crosstalk can be defined as the interplay between different nuclear
receptors or between their overlapping signalling pathways. A subset of nuclear receptors …

The immune system is under control of the circadian clock. Many of the circadian rhythms
observed in the immune system originate in direct interactions between components of the …

Circadian dysfunction is a common attribute of many neurodegenerative diseases, most of
which are associated with neuroinflammation. Circadian rhythm dysfunction has been …

Background Circadian disturbance is a common nonmotor complaint in Parkinson's disease
(PD). The molecular basis underlying circadian rhythm in PD is poorly understood …

The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …

A promising new therapeutic target for the treatment of Alzheimer's disease (AD) is the
circadian system. Although patients with AD are known to have abnormal circadian rhythms …

Abstract REV-ERBα (NR1D1) is a circadian clock component that functions as a
transcriptional repressor. Due to its role in direct modulation of metabolic genes, REV-ERBα …