Hyaluronic acid in ocular drug delivery

X Zhang, D Wei, Y Xu, Q Zhu - Carbohydrate Polymers, 2021 - Elsevier
As a naturally-occurring polysaccharide which could be found in various ophthalmic tissues,
hyaluronic acid (HA) has a wide range of applications in the eye, including treatment of dry …

Hyaluronic acid based microneedle array: Recent applications in drug delivery and cosmetology

I Saha, VK Rai - Carbohydrate Polymers, 2021 - Elsevier
Microneedles are micron-sized arrays of needles that facilitate drug delivery for local and
systemic effects. Hyaluronic acid (HA) is a glycosaminoglycan and is an indigenous …

Tailoring hyaluronic acid hydrogels for biomedical applications

Z Luo, Y Wang, J Li, J Wang, Y Yu… - Advanced Functional …, 2023 - Wiley Online Library
Hyaluronic acid (HA) is an attractive anionic polysaccharide polymer with inherent
pharmacological properties and versatile chemical groups for modification. Due to their …

A dandelion polysaccharide and its selenium nanoparticles: Structure features and evaluation of anti-tumor activity in zebrafish models

S Zhang, Z Song, L Shi, L Zhou, J Zhang, J Cui… - Carbohydrate …, 2021 - Elsevier
In this study, an inulin fructan (TMP50-2) with moderate anti-tumor activity was obtained from
dandelion. To further improve the anti-tumor activity of TMP50-2, a monodisperse and stable …

Hyaluronate and its derivatives for customized biomedical applications

H Kim, H Jeong, S Han, S Beack, BW Hwang, M Shin… - Biomaterials, 2017 - Elsevier
Since hyaluronate (HA) was firstly isolated from the vitreous of bovine eyes in 1934, HA has
been widely investigated for various biomedical applications. As a naturally-occurring …

Marine polymeric microneedles for transdermal drug delivery

T Moniz, SAC Lima, S Reis - Carbohydrate Polymers, 2021 - Elsevier
Transdermal drug delivery is considered one of the most attractive routes for administration
of pharmaceutic and cosmetic active ingredients due to the numerous advantages …

Considerations in the use of microneedles: pain, convenience, anxiety and safety

HR Jeong, HS Lee, IJ Choi, JH Park - Journal of drug targeting, 2017 - Taylor & Francis
Transdermal delivery using microneedles is gaining increasing attention from
pharmaceutical and cosmetic companies as one of the promising drug delivery methods …

Advances in the application of microneedles in the treatment of local organ diseases

J Li, R Ge, K Lin, J Wang, Y He, H Lu, H Dong - Small, 2024 - Wiley Online Library
In recent years, microneedles (MNs) have attracted a lot of attention due to their microscale
sizes and high surface area (500–1000 µm in length), allowing pain‐free and efficient drug …

Hyaluronic acid microneedles‐laden collagen cryogel plugs for ocular drug delivery

K Saraswathy, G Agarwal… - Journal of Applied …, 2020 - Wiley Online Library
Particle loaded hydrogels have shown to provide prolonged delivery of drug in a controlled
manner. We propose that embedding drug‐loaded hyaluronic acid (HA) microneedles in …

Antimicrobial activity and biocompatibility of slow-release hyaluronic acid-antibiotic conjugated particles

Z Zhang, SS Suner, DA Blake, RS Ayyala… - International Journal of …, 2020 - Elsevier
Here, the aim was to design and use a long-lasting antibiotic release system for prevention
of postoperative infections in ophthalmic surgery. Ciprofloxacin and vancomycin-conjugated …