De novo variants in the RNU4-2 snRNA cause a frequent neurodevelopmental syndrome

Y Chen, R Dawes, HC Kim, A Ljungdahl, SL Stenton… - Nature, 2024 - nature.com
Around 60% of individuals with neurodevelopmental disorders (NDD) remain undiagnosed
after comprehensive genetic testing, primarily of protein-coding genes. Large genome …

Ferroptosis in the colon epithelial cells as a therapeutic target for ulcerative colitis

A Yokote, N Imazu, J Umeno, K Kawasaki… - Journal of …, 2023 - Springer
Background Ferroptosis, a type of programmed cell death triggered by oxidative stress, was
suspected to play a role in ulcerative colitis. Indigo naturalis is highly effective against …

Microbial hitchhikers harbouring antimicrobial-resistance genes in the riverine plastisphere

V Zadjelovic, RJ Wright, C Borsetto, J Quartey… - Microbiome, 2023 - Springer
Background The widespread nature of plastic pollution has given rise to wide scientific and
social concern regarding the capacity of these materials to serve as vectors for pathogenic …

Rhizobia Contribute to Salinity Tolerance in Common Beans (Phaseolus vulgaris L.)

C Wekesa, GO Asudi, P Okoth, M Reichelt, JO Muoma… - Cells, 2022 - mdpi.com
Rhizobia are soil bacteria that induce nodule formation on leguminous plants. In the
nodules, they reduce dinitrogen to ammonium that can be utilized by plants. Besides …

Tumour cell apoptosis modulates the colorectal cancer immune microenvironment via interleukin-8-dependent neutrophil recruitment

V Schimek, K Strasser, A Beer, S Göber… - Cell Death & …, 2022 - nature.com
Sporadic apoptosis of tumour cells is a commonly observed feature of colorectal cancer
(CRC) and strongly correlates with adverse patient prognosis. The uptake of apoptotic cell …

Therapeutically expanded human regulatory T-cells are super-suppressive due to HIF1A induced expression of CD73

LB Jarvis, DB Rainbow, V Coppard, SK Howlett… - Communications …, 2021 - nature.com
The adoptive transfer of regulatory T-cells (Tregs) is a promising therapeutic approach in
transplantation and autoimmunity. However, because large cell numbers are needed to …

Structural modeling of nanobodies: a benchmark of state-of-the-art artificial intelligence programs

MS Valdés-Tresanco, ME Valdés-Tresanco… - Molecules, 2023 - mdpi.com
The number of applications for nanobodies is steadily expanding, positioning these
molecules as fast-growing biologic products in the biotechnology market. Several of their …

Proteomic characterisation of triple negative breast cancer cells following CDK4/6 inhibition

M Beykou, M Arias-Garcia, TI Roumeliotis… - Scientific data, 2022 - nature.com
When used in combination with hormone treatment, Palbociclib prolongs progression-free
survival of patients with hormone receptor positive breast cancer. Mechanistically …

A semi-automated and high-throughput approach for the detection of honey bee viruses in bee samples

SL Nikulin, PJ Hesketh-Best, DA Mckeown, M Spivak… - PloS one, 2024 - journals.plos.org
Deformed wing virus (DWV) was first detected in dead honey bees in 1982 but has been in
honey bees for at least 300 years. Due to its high prevalence and virulence, they have been …

Statistical comparison between in-person and online general chemistry exam outcomes: A COVID-induced case study

B Sorenson, K Hanson - Journal of Chemical Education, 2023 - ACS Publications
In spring 2020, the chemical education community faced an abrupt transition from in-person
to online classes, which also necessitated online assessments. Building upon an existing …