Hepatocellular carcinoma (HCC) is an aggressive human cancer with increasing incidence
worldwide. Multiple efforts have been made to explore pharmaceutical therapies to treat …

The pentose phosphate pathway (PPP), which branches from glycolysis at the first
committed step of glucose metabolism, is required for the synthesis of ribonucleotides and is …

It has been appreciated for nearly 100 years that cancer cells are metabolically distinct from
resting tissues. More recently understood is that this metabolic phenotype is not unique to …

Cancer cells are well documented to rewire their metabolism and energy production
networks to support and enable rapid proliferation, continuous growth, survival in harsh …

Interest in cancer metabolism has increased in recent years. The pentose phosphate
pathway (PPP) is a major glucose catabolism pathway that directs glucose flux to its …

Cancer therapy has long relied on the rapid proliferation of tumour cells for effective
treatment. However, the lack of specificity in this approach often leads to undesirable side …

The essential hallmarks of cancer are intertwined with an altered cancer cell-intrinsic
metabolism, either as a consequence or as a cause. As an example, the resistance of …

Evidence indicates that hypoxia and oxidative stress can control metabolic reprogramming
of cancer cells and other cells in tumor microenvironments and that the reprogrammed …

The function of p53 is best understood in response to genotoxic stress, but increasing
evidence suggests that p53 also plays a key role in the regulation of metabolic homeostasis …

Radiotherapy, an important treatment modality in oncology, kills cells through induction of
oxidative stress. However, malignant tumors vary in their response to irradiation as a …