HIV infection

LG Bekker, C Beyrer, N Mgodi, SR Lewin… - Nature Reviews …, 2023 - nature.com
The AIDS epidemic has been a global public health issue for more than 40 years and has
resulted in~ 40 million deaths. AIDS is caused by the retrovirus, HIV-1, which is transmitted …

Viral pandemics of the last four decades: pathophysiology, health impacts and perspectives

S Roychoudhury, A Das, P Sengupta, S Dutta… - International journal of …, 2020 - mdpi.com
The last four decades has witnessed some of the deadliest viral pandemics with far-reaching
consequences. These include the Human Immunodeficiency Virus (HIV)(1981), Severe …

Antiviral polymers: past approaches and future possibilities

RH Bianculli, JD Mase, MD Schulz - Macromolecules, 2020 - ACS Publications
Treating a viral disease is no simple feat. Drug resistance, latent reservoirs in the body,
emerging novel viruses, and a frequent lack of specific treatments all complicate antiviral …

Origins of HIV and the AIDS pandemic

PM Sharp, BH Hahn - Cold Spring …, 2011 - perspectivesinmedicine.cshlp.org
Acquired immunodeficiency syndrome (AIDS) of humans is caused by two lentiviruses,
human immunodeficiency viruses types 1 and 2 (HIV-1 and HIV-2). Here, we describe the …

Application of CRISPR/Cas9-based gene editing in HIV-1/AIDS therapy

Q Xiao, D Guo, S Chen - Frontiers in cellular and infection …, 2019 - frontiersin.org
Despite the fact that great efforts have been made in the prevention and therapy of HIV-1
infection, HIV-1/AIDS remains a major threat to global human health. Highly active …

Acute HIV-1 infection

MS Cohen, GM Shaw, AJ McMichael… - New England Journal …, 2011 - Mass Medical Soc
Acute HIV-1 Infection | New England Journal of Medicine Skip to main content Access provided
byTE WHATU ORA HEALTH NEW ZEALAND COUNTIES MANUKAU The New England …

The seminal microbiome in health and disease

S Altmäe, JM Franasiak, R Mändar - Nature Reviews Urology, 2019 - nature.com
Owing to the fact that there are more microbial than human cells in our body and that
humans contain more microbial than human genes, the microbiome has huge potential to …

Phenotypic properties of transmitted founder HIV-1

NF Parrish, F Gao, H Li, EE Giorgi… - Proceedings of the …, 2013 - National Acad Sciences
Defining the virus–host interactions responsible for HIV-1 transmission, including the
phenotypic requirements of viruses capable of establishing de novo infections, could be …

Pathogenic mechanisms of HIV disease

S Moir, TW Chun, AS Fauci - Annual review of pathology …, 2011 - annualreviews.org
Human immunodeficiency virus (HIV) infection is generally characterized by inefficient viral
transmission; an acute phase of intense viral replication and dissemination to lymphoid …

Exposure to HIV-1 directly impairs mucosal epithelial barrier integrity allowing microbial translocation

A Nazli, O Chan, WN Dobson-Belaire, M Ouellet… - PLoS …, 2010 - journals.plos.org
While several clinical studies have shown that HIV-1 infection is associated with increased
permeability of the intestinal tract, there is very little understanding of the mechanisms …