Viral pandemics of the last four decades: pathophysiology, health impacts and perspectives
The last four decades has witnessed some of the deadliest viral pandemics with far-reaching
consequences. These include the Human Immunodeficiency Virus (HIV)(1981), Severe …
consequences. These include the Human Immunodeficiency Virus (HIV)(1981), Severe …
Antiviral polymers: past approaches and future possibilities
Treating a viral disease is no simple feat. Drug resistance, latent reservoirs in the body,
emerging novel viruses, and a frequent lack of specific treatments all complicate antiviral …
emerging novel viruses, and a frequent lack of specific treatments all complicate antiviral …
Origins of HIV and the AIDS pandemic
Acquired immunodeficiency syndrome (AIDS) of humans is caused by two lentiviruses,
human immunodeficiency viruses types 1 and 2 (HIV-1 and HIV-2). Here, we describe the …
human immunodeficiency viruses types 1 and 2 (HIV-1 and HIV-2). Here, we describe the …
Application of CRISPR/Cas9-based gene editing in HIV-1/AIDS therapy
Q Xiao, D Guo, S Chen - Frontiers in cellular and infection …, 2019 - frontiersin.org
Despite the fact that great efforts have been made in the prevention and therapy of HIV-1
infection, HIV-1/AIDS remains a major threat to global human health. Highly active …
infection, HIV-1/AIDS remains a major threat to global human health. Highly active …
The seminal microbiome in health and disease
Owing to the fact that there are more microbial than human cells in our body and that
humans contain more microbial than human genes, the microbiome has huge potential to …
humans contain more microbial than human genes, the microbiome has huge potential to …
Phenotypic properties of transmitted founder HIV-1
Defining the virus–host interactions responsible for HIV-1 transmission, including the
phenotypic requirements of viruses capable of establishing de novo infections, could be …
phenotypic requirements of viruses capable of establishing de novo infections, could be …
Pathogenic mechanisms of HIV disease
Human immunodeficiency virus (HIV) infection is generally characterized by inefficient viral
transmission; an acute phase of intense viral replication and dissemination to lymphoid …
transmission; an acute phase of intense viral replication and dissemination to lymphoid …
Exposure to HIV-1 directly impairs mucosal epithelial barrier integrity allowing microbial translocation
While several clinical studies have shown that HIV-1 infection is associated with increased
permeability of the intestinal tract, there is very little understanding of the mechanisms …
permeability of the intestinal tract, there is very little understanding of the mechanisms …