Targeting the gut microbiota for cancer therapy

MR Fernandes, P Aggarwal, RGF Costa… - Nature Reviews …, 2022 - nature.com
Growing evidence suggests that the gut microbiota modulates the efficacy and toxicity of
cancer therapy, most notably immunotherapy and its immune-related adverse effects. The …

Short chain fatty acids and its producing organisms: An overlooked therapy for IBD?

S Deleu, K Machiels, J Raes, K Verbeke, S Vermeire - EBioMedicine, 2021 - thelancet.com
The gut microbiome and the intestinal immune system are driving contributors to
inflammatory bowel diseases (IBD). Both have an important signalling factor in common …

Type 1 diabetes mellitus as a disease of the β-cell (do not blame the immune system?)

BO Roep, S Thomaidou, R van Tienhoven… - Nature Reviews …, 2021 - nature.com
Type 1 diabetes mellitus is believed to result from destruction of the insulin-producing β-cells
in pancreatic islets that is mediated by autoimmune mechanisms. The classic view is that …

Impact of bacterial metabolites on gut barrier function and host immunity: a focus on bacterial metabolism and its relevance for intestinal inflammation

N Gasaly, P De Vos, MA Hermoso - Frontiers in immunology, 2021 - frontiersin.org
The diverse and dynamic microbial community of the human gastrointestinal tract plays a
vital role in health, with gut microbiota supporting the development and function of the gut …

Gut microbiota impact on the peripheral immune response in non-alcoholic fatty liver disease related hepatocellular carcinoma

J Behary, N Amorim, XT Jiang, A Raposo… - Nature …, 2021 - nature.com
The gut microbiota is reported to modulate the immune response in hepatocellular
carcinoma (HCC). Here, we employ metagenomic and metabolomic studies to characterise …

The immunomodulatory functions of butyrate

MT Siddiqui, GAM Cresci - Journal of inflammation research, 2021 - Taylor & Francis
The gastrointestinal (GI) system contains many different types of immune cells, making it a
key immune organ system in the human body. In the last decade, our knowledge has …

Gut microbiota-derived short-chain fatty acids regulate IL-17 production by mouse and human intestinal γδ T cells

L Dupraz, A Magniez, N Rolhion, ML Richard… - Cell Reports, 2021 - cell.com
Summary Gut interleukin-17A (IL-17)-producing γδ T cells are tissue-resident cells that are
involved in both host defense and regulation of intestinal inflammation. However, factors that …

[HTML][HTML] The role of gut microbiota in T cell immunity and immune mediated disorders

JA Shim, JH Ryu, Y Jo, C Hong - International journal of biological …, 2023 - ncbi.nlm.nih.gov
Gut microbiota was only considered as a commensal organism that aids in digestion, but
recent studies revealed that the microbiome play a critical role in both physiological and …

Microbial metabolites and gut immunology

T Takeuchi, Y Nakanishi, H Ohno - Annual Review of …, 2024 - annualreviews.org
The intestine is the largest peripheral lymphoid organ in animals, including humans, and
interacts with a vast array of microorganisms called the gut microbiota. Comprehending the …

Butyrate and the fine-tuning of colonic homeostasis: implication for inflammatory bowel diseases

N Gasaly, MA Hermoso, M Gotteland - International journal of molecular …, 2021 - mdpi.com
This review describes current evidence supporting butyrate impact in the homeostatic
regulation of the digestive ecosystem in health and inflammatory bowel diseases (IBDs) …