Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease associated with
synovial tissue proliferation, pannus formation, cartilage destruction, and systemic …

Rheumatoid arthritis (RA) is an inflammatory autoimmune disease involving symmetric joints
and is generally characterized by persistent pain, tenderness, and destruction of joints. The …

T-cells are crucial in maintanence of intestinal homeostasis, however, it is still unclear how
microbiota metabolites regulate T-effector cells. Here we show gut microbiota-derived short …

Ligation of the CD28 receptor on T cells provides a critical second signal alongside T cell
receptor (TCR) ligation for naive T cell activation. Here, we discuss the expression, structure …

Rheumatoid arthritis (RA) is the most common systemic inflammatory rheumatic disease. It is
associated with significant burden at the patient and societal level. Extensive efforts have …

Psoriasis vulgaris is a common, chronic inflammatory skin disease with a complex etiology
involving genetic risk factors and environmental triggers. Here we describe the many known …

A major challenge in human genetics is to devise a systematic strategy to integrate disease-
associated variants with diverse genomic and biological data sets to provide insight into …

Autophagy is a fundamental eukaryotic pathway that has multiple effects on immunity.
Autophagy is induced by pattern recognition receptors and, through autophagic adaptors, it …

Background: Butyric acid (BA) is a short-chain fatty acid (SCFA) with anti-inflammatory
properties, which promotes intestinal barrier function. Medium-chain fatty acids (MCFA) …

Phagocytic cells of the immune system must constantly survey for, recognize, and efficiently
clear the billions of cellular corpses that arise as a result of development, stress, infection, or …