Engram neurons: Encoding, consolidation, retrieval, and forgetting of memory
A Guskjolen, MS Cembrowski - Molecular psychiatry, 2023 - nature.com
Tremendous strides have been made in our understanding of the neurobiological substrates
of memory–the so-called memory “engram”. Here, we integrate recent progress in the …
of memory–the so-called memory “engram”. Here, we integrate recent progress in the …
[HTML][HTML] Hippocampal GABAergic interneurons and memory
One of the most captivating questions in neuroscience revolves around the brain's ability to
efficiently and durably capture and store information. It must process continuous input from …
efficiently and durably capture and store information. It must process continuous input from …
Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia
Altered olfactory function is a common symptom of COVID-19, but its etiology is unknown. A
key question is whether SARS-CoV-2 (CoV-2)–the causal agent in COVID-19–affects …
key question is whether SARS-CoV-2 (CoV-2)–the causal agent in COVID-19–affects …
[HTML][HTML] Reconstruction of 1,000 projection neurons reveals new cell types and organization of long-range connectivity in the mouse brain
Neuronal cell types are the nodes of neural circuits that determine the flow of information
within the brain. Neuronal morphology, especially the shape of the axonal arbor, provides …
within the brain. Neuronal morphology, especially the shape of the axonal arbor, provides …
Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells
The hippocampal-entorhinal system supports cognitive functions, has lifelong neurogenic
capabilities in many species, and is selectively vulnerable to Alzheimer's disease. To …
capabilities in many species, and is selectively vulnerable to Alzheimer's disease. To …
Whole-brain profiling of cells and circuits in mammals by tissue clearing and light-sheet microscopy
Tissue clearing and light-sheet microscopy have a 100-year-plus history, yet these fields
have been combined only recently to facilitate novel experiments and measurements in …
have been combined only recently to facilitate novel experiments and measurements in …
Heterogeneity within classical cell types is the rule: lessons from hippocampal pyramidal neurons
MS Cembrowski, N Spruston - Nature Reviews Neuroscience, 2019 - nature.com
The mechanistic operation of brain regions is often interpreted by partitioning constituent
neurons into 'cell types'. Historically, such cell types were broadly defined by their …
neurons into 'cell types'. Historically, such cell types were broadly defined by their …
Integration of gene expression and brain-wide connectivity reveals the multiscale organization of mouse hippocampal networks
Understanding the organization of the hippocampus is fundamental to understanding brain
function related to learning, memory, emotions, and diseases such as Alzheimer's disease …
function related to learning, memory, emotions, and diseases such as Alzheimer's disease …
Multimodal mapping of cell types and projections in the central nucleus of the amygdala
The central nucleus of the amygdala (CEA) is a brain region that integrates external and
internal sensory information and executes innate and adaptive behaviors through distinct …
internal sensory information and executes innate and adaptive behaviors through distinct …
Multiomic profiling of the acute stress response in the mouse hippocampus
The acute stress response mobilizes energy to meet situational demands and re-establish
homeostasis. However, the underlying molecular cascades are unclear. Here, we use a brief …
homeostasis. However, the underlying molecular cascades are unclear. Here, we use a brief …