Permanent disabilities following CNS injuries result from the failure of injured axons to
regenerate and rebuild functional connections with their original targets. By contrast, injury …

Schizophrenia is a severe neuropsychiatric disorder with a longstanding history of
neurobiological investigation. Although the underlying causal mechanisms remain …

Lysosomes have been classically considered terminal degradative organelles, but in recent
years they have been found to participate in many other cellular processes, including killing …

The ability of lysosomes to move within the cytoplasm is important for many cellular
functions. This ability is particularly critical in neurons, which comprise vast, highly …

Our earlier work has shown that genomic risk for schizophrenia converges with early life
complications in affecting risk for the disorder and sex-biased neurodevelopmental …

Specific cell populations may have unique contributions to schizophrenia but may be missed
in studies of homogenate tissue. Here laser capture microdissection followed by RNA …

Genome-wide association studies (GWASs) have identified over 180 independent
schizophrenia risk loci. Nevertheless, how the risk variants in the reported loci confer …

Schizophrenia is a neurodevelopmental brain disorder whose genetic risk is associated with
shifting clinical phenomena across the life span. We investigated the convergence of …

Human induced pluripotent stem cells (hiPSCs) are a powerful model of neural
differentiation and maturation. We present a hiPSC transcriptomics resource on …

RNA splicing is a key mechanism linking genetic variation with psychiatric disorders.
Splicing profiles are particularly diverse in brain and difficult to accurately identify and …