Antimicrobial peptides: Role in human disease and potential as immunotherapies
Antimicrobial peptides (AMPs) have evolved through billions of years as part of our innate
immune system. These agents are produced by various cells throughout the human body …
immune system. These agents are produced by various cells throughout the human body …
Antimicrobial host defence peptides: immunomodulatory functions and translational prospects
AM van der Does, PS Hiemstra… - … Peptides: Basics for …, 2019 - Springer
Cationic host defence peptides (CHDPs), also known as antimicrobial peptides, exhibit a
wide range of activities contributing to immune responses and resolution of infections …
wide range of activities contributing to immune responses and resolution of infections …
[HTML][HTML] Cathelicidins have direct antiviral activity against respiratory syncytial virus in vitro and protective function in vivo in mice and humans
SM Currie, E Gwyer Findlay, AJ McFarlane… - The Journal of …, 2016 - journals.aai.org
Respiratory syncytial virus (RSV) is a leading cause of respiratory tract infection in infants,
causing significant morbidity and mortality. No vaccine or specific, effective treatment is …
causing significant morbidity and mortality. No vaccine or specific, effective treatment is …
Repurposing HDAC inhibitors to enhance ribonuclease 4 and 7 expression and reduce urinary tract infection
L Schwartz, MS Bochter, A Simoni… - Proceedings of the …, 2023 - National Acad Sciences
With the emergence of antibiotic-resistant bacteria, innovative approaches are needed for
the treatment of urinary tract infections. Boosting antimicrobial peptide expression may …
the treatment of urinary tract infections. Boosting antimicrobial peptide expression may …
Antimicrobial peptides and innate lung defenses: role in infectious and noninfectious lung diseases and therapeutic applications
PS Hiemstra, GD Amatngalim, AM van der Does… - Chest, 2016 - Elsevier
Respiratory infections are a major clinical problem, and treatment is increasingly
complicated by the emergence of microbial antibiotic resistance. Development of new …
complicated by the emergence of microbial antibiotic resistance. Development of new …
Upregulating human cathelicidin antimicrobial peptide LL-37 expression may prevent severe COVID-19 inflammatory responses and reduce microthrombosis
KM Aloul, JE Nielsen, EB Defensor, JS Lin… - Frontiers in …, 2022 - frontiersin.org
COVID-19 is characterized by hyperactivation by inflammatory cytokines and recruitment of
macrophages, neutrophils, and other immune cells, all hallmarks of a strong inflammatory …
macrophages, neutrophils, and other immune cells, all hallmarks of a strong inflammatory …
The network of colonic host defense peptides as an innate immune defense against enteropathogenic bacteria
Host defense peptides, abundantly secreted by colonic epithelial cells and leukocytes, are
proposed to be critical components of an innate immune response in the colon against …
proposed to be critical components of an innate immune response in the colon against …
Host directed therapy against infection by boosting innate immunity
The innate immune system constitutes the first line of defense against invading pathogens,
regulating the normal microbiota and contributes to homeostasis. Today we have obtained …
regulating the normal microbiota and contributes to homeostasis. Today we have obtained …
The potential for immunoglobulins and host defense peptides (HDPs) to reduce the use of antibiotics in animal production
Innate defense mechanisms are aimed at quickly containing and removing infectious
microorganisms and involve local stromal and immune cell activation, neutrophil recruitment …
microorganisms and involve local stromal and immune cell activation, neutrophil recruitment …
Potent inducers of endogenous antimicrobial peptides for host directed therapy of infections
A new concept for treatment of infections is induction of our own antimicrobial peptides and
the presented novel class of inducer, aroylated phenylenediamines (APDs), gives up to 20 …
the presented novel class of inducer, aroylated phenylenediamines (APDs), gives up to 20 …